Arifon - General Information:

A benzamide-sulfonamide-indole. It is called a thiazide-like diuretic but structure is different enough (lacking the thiazo-ring) so it is not clear that the mechanism is comparable. [PubChem]

Related offer from MedStore:

LozolGeneric Lozol (Indapamide) - 1.5mg 30 pills for $52.65
Lozol (Indapamide) is a diuretic used to treat high blood pressure and swelling due to excess fluid in the body. It may also be used to treat other conditions as determined by your doctor.


Arifon is an antihypertensive and a diuretic. It contains both a polar sulfamoyl chlorobenzamide moiety and a lipid- soluble methylindoline moiety. Arifon bears a structural similarity to the triazide diuretics which are known to decrease vascular smooth muscle reactivity. However, it differs chemically from the thiazides in that it does not possess the thiazide ring system and contains only one sulfonamide group. Arifon appears to cause vasodilation, probably by inhibiting the passage of calcium and other ions (sodium, potassium) across membranes. This same effect may cause hypokalcemia in susceptible individuals. Arifon has also been shown to cause uterine myometrial relaxation in experimental animals. Overall, indapamide has an extra-renal antihypertensive action resulting in a decrease in vascular hyperreactivity and a reduction in total peripheral and arteriolar resistance.

Arifon for patients

Arifon Interactions

Arifon Contraindications

Anuria. Known hypersensitivity to indapamide or to other sulfonamide-derived drugs.

Additional information about Arifon

Arifon Indication: For the treatment of hypertension, alone or in combination with other antihypertensive drugs as well as for the treatment of salt and fluid retention associated with congestive heart failure or edema from pregnancy.
Mechanism Of Action: Arifon blocks the slow component of delayed rectifier potassium current (IKs) without altering the rapid component (IKr) or the inward rectifier current. Specifically it blocks or antagonizes the action the proteins KCNQ1 and KCNE1. Arifon is also thought to stimulate the synthesis of the vasodilatory hypotensive prostaglandin PGE2.
Drug Interactions: Amantadine The diuretic increases the adverse effect of amantadine
Deslanoside Possible electrolyte variations and arrhythmias
Diazoxide Significant hyperglycemic effect
Digitoxin Possible electrolyte variations and arrhythmias
Digoxin Possible electrolyte variations and arrhythmias
Dofetilide Increased risk of cardiotoxicity and arrhythmias
Lithium The thiazide diuretic increases serum levels of lithium
Food Interactions: Take without regard to meals. Magnesium, potassium and zinc needs increased.
Generic Name: Indapamide
Synonyms: Indapamida [INN-Spanish]; Indapamidum [INN-Latin]
Drug Category: Antihypertensive Agents; Diuretics
Drug Type: Small Molecule; Approved
Other Brand Names containing Indapamide: Apo-Indapamide; Arifon; Bajaten; Cormil; Damide; Fludex; Gen-Indapamide; Idapamide; Indaflex; Indamol; Ipamix; Lozide; Lozol; Natrilix; Natrix; Noranat; Novo-Indapamide; Nu-Indapamide; Pressurai; Tandix; Tertensif; Veroxil;
Absorption: Rapidly absorbed from gastrointestinal tract.
Toxicity (Overdose): Side effects include electrolyte imbalance (potassium or salt depletion due to too much fluid loss), nausea, stomach disorders, vomiting, weakness
Protein Binding: 71-79%
Biotransformation: Primarily hepatic. Indapamide is an extensively metabolized drug with only about 7+ACU- of the total dose administered, recovered in the urine as unchanged drug during the first 48 hours after administration.
Half Life: 14 hours (biphasic)
Dosage Forms of Arifon: Tablet Oral
Chemical IUPAC Name: 4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoylbenzamide
Chemical Formula: C16H16ClN3O3S
Indapamide on Wikipedia:
Organisms Affected: Humans and other mammals

Bookmark or Share this page

»Get link codes for this page«
(HTML/BB code)

Search by name browsing our [A-Z] index:


Search by Categories:

See a list of all drugs for sale »

Top5 meds in current month:

*based on number of page views on Flexyx

Visit our friends:

brand and generic ed pills Russian Scientific Center for Restorative Traumatology and Orthopaedics in the name of academician G.A.Ilizarov

Related News

Tue, 03 Apr 2012
Wissenschaft Blog - Aktuelles multidisziplinäre Forschung - MyScienceWork
20 März 2012 von Olivier Arifon. This paper seeks to present how digital communication contributes to modifying processes of popular influence, activism and lobbying on companies and governments in East Asia civil societies. It will be guided by identifying methods, trends and similar behavior to westerns countries.
Source: »

Tue, 06 Dec 2011
Don Croner's World Wide Wanders - Naqshbandi's Tomb - Uzbekistan - Bukhara
During a recent sojourn in Uzbekistan I wandered by his tomb, located in the village Kasri Arifon eight or so miles from Bukhara. Entrance to the Mausoleum of Baqshbandi. Tomb of Baqshbandi. Monument in the Mausoleum Complex. Uzbekistan Roses in all their resplendent glory just outside the Mausoleum Complex.
Source: »

Sat, 04 Jun 2011
The Dao of the Information Society in China
The 'art du lien' – a term coined by the French communication scientists Olivier Arifon and Philippe Ricaud (Arifon and Ricaud 2005) – or 'connecting art' deals less with opposition or separation than with connection.
Source: »

Thanks for visiting us!