Aspatofort - General Information:One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter. [PubChem]
Pharmacology:L-aspartate is considered a non-essential amino acid, meaning that, under normal physiological conditions, sufficient amounts of the amino acid are synthesized in the body to meet the body's requirements. L-aspartate is formed by the transamination of the Krebs cycle intermediate oxaloacetate. The amino acid serves as a precursor for synthesis of proteins, oligopeptides, purines, pyrimidines, nucleic acids and L-arginine. L-aspartate is a glycogenic amino acid, and it can also promote energy production via its metabolism in the Krebs cycle. These latter activities were the rationale for the claim that supplemental aspartate has an anti-fatigue effect on skeletal muscle, a claim that was never confirmed.
Aspatofort for patients
No drug, nutritional supplement, food or herb interactions are known.
L-aspartate supplementation is contraindicated in those hypersensitive to any component of the preparation.
Additional information about AspatofortAspatofort Indication: There is no support for the claim that aspartates are exercise performance enhancers, i.e. ergogenic aids.
Mechanism Of Action: There are also claims that L-aspartate has ergogenic effects, that it enhances performance in both prolonged exercise and short intensive exercise. It is hypothesized that L-aspartate, especially the potassium magnesium aspartate salt, spares stores of muscle glycogen and/or promotes a faster rate of glycogen resynthesis during exercise. It has also been hypothesized that L-aspartate can enhance short intensive exercise by serving as a substrate for energy production in the Krebs cycle and for stimulating the purine nucleotide cycle.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: L-Aspartic Acid
Synonyms: (+)-Aspartic acid; (2S)-Aspartic acid; (L)-Aspartic acid; (S)-Aminobutanedioic acid; (S)-Aspartic acid; Acide aspartique [INN-French]; Acido aspartico [INN-Spanish]; Acidum asparticum; Aminosuccinic acid; Asparagic acid; Asparaginic acid; Asparaginsaeure [German]; Aspartate; Aspartic acid; H-Asp-OH; L-(+)-Aspartic acid; L-2-Aminobutanedioic acid; L-Aminosuccinic acid; L-Asparagic acid; L-Asparaginic acid; L-Asparaginsaeure; L-Asparaginsyra; L-Aspartinsaeure
Drug Category: Dietary supplement; Micronutrient; Non-Essential Amino Acids
Drug Type: Small Molecule; Nutraceutical; Approved
Other Brand Names containing L-Aspartic Acid: Aspatofort;
Absorption: Absorbed from the small intestine by an active transport process
Toxicity (Overdose): Mild gastrointestinal side effects including diarrhea. LD50 (rat) > 5,000 mg/kg.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Aspatofort: Not Available
Chemical IUPAC Name: (2S)-2-aminobutanedioic acid
Chemical Formula: C4H7NO4
L-Aspartic Acid on Wikipedia: http://en.wikipedia.org/wiki/L-Aspartic_Acid
Organisms Affected: Humans and other mammals
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