Ataraxoid - General Information:

A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite cetirizine, it does cause drowsiness. It is also effective as an antiemetic, for relief of anxiety and tension, and as a sedative. [PubChem]

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AtaraxGeneric Atarax (Hydroxyzin) - 10mg 90 tabs for $58.73
Atarax (Hydroxyzine) is an antihistamine used to treat anxiety, to relieve itching caused by allergic conditions, and to cause drowsiness. It may also be used to treat other conditions as determined by your doctor.

Pharmacology:

Ataraxoid, a piperazine antihistamine structurally related to buclizine, cyclizine, and meclizine, is used to treat histamine-mediated pruritus or pruritus due to allergy, nausea and vomiting, and, in combination with an opiate agonist, anxiolytic pain. Ataraxoid is also used as a perioperative sedative and anxiolytic and to manage acute alcohol withdrawal. Ataraxoid's active metabolite, cetirizine, is also used as an H1-antagonist.

Ataraxoid for patients

Drug Uses
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This medicine is an antihistamine used to treat anxiety and to relieve itching.

General Information
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If you have any questions about your medicine, talk to your health care provider.

How Drug Works
--------------------------------------------------------------------------------

This medicine blocks the action of histamine in the body.

How Taken
--------------------------------------------------------------------------------

Follow the directions given to you by your doctor. This medicine is taken orally
and may be taken with food if it upsets your stomach. Do not take more of this
medicine than recommended.

Possible Side Effects
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drowsiness
dry mouth

Warnings/Precautions
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Do NOT drive or perform other dangerous tasks while taking this medicine.
This medicine can increase the effects of alcohol.
Alcohol can add to the side effects of this medicine.
Do NOT take this medicine if you are allergic to hydroxyzine or any of the ingredients.


Overdose
--------------------------------------------------------------------------------

Seek medical attention immediately. For non emergencies, contact your local or regional
poison control center

Drug Interactions
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Missed Dose
--------------------------------------------------------------------------------

Take your next dose as soon as you remember. If it is time for your next dose, skip the
missed dose and go back to your regular schedule. Do not double doses.

Storage
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Keep this medication in the container it came in, tightly closed, and out of reach of
children. Store it at room temperature and away from excess heat and moisture (not in
the bathroom). Throw away any medication that is outdated or no longer needed.

Pregnancy/Nursing
--------------------------------------------------------------------------------

If you are or plan on becoming pregnant, talk to your doctor about the benefits versus
the risks of using this medicine while pregnant. For nursing mothers, this medicine is
excreted in breast milk. If you plan to breast feed, talk to your doctor first.

More Information
--------------------------------------------------------------------------------

For more information, talk to your doctor, pharmacist or health care provider.

Ataraxoid Interactions

THE POTENTIATING ACTION OF HYDROXYZINE MUST BE CONSIDERED WHEN THE DRUG IS USED IN CONJUNCTION WITH CENTRAL NERVOUS SYSTEM DEPRESSANTS SUCH AS NARCOTICS, NON-NARCOTIC ANALGESICS AND BARBITURATES. Therefore when central nervous system depressants are administered concomitantly with hydroxyzine their dosage should be reduced.

Since drowsiness may occur with use of this drug, patients should be warned of this possibility and cautioned against driving a car or operating dangerous machinery while taking Atarax. Patients should be advised against the simultaneous use of other CNS depressant drugs, and cautioned that the effect of alcohol may be increased.

Ataraxoid Contraindications

Hydroxyzine, when administered to the pregnant mouse, rat, and rabbit, induced fetal abnormalities in the rat and mouse at doses substantially above the human therapeutic range. Clinical data in human beings are inadequate to establish safety in early pregnancy. Until such data are available, hydroxyine is contraindicated in early pregnancy.

Hydroxyzine is contraindicated for patients who have shown a previous hypersensitivity to it.


Additional information about Ataraxoid

Ataraxoid Indication: For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria.
Mechanism Of Action: Ataraxoid competes with histamine for binding at H1-receptor sites on the effector cell surface, resulting in suppression of histaminic edema, flare, and pruritus. The sedative properties of hydroxyzine occur at the subcortical level of the CNS. Secondary to its central anticholinergic actions, hydroxyzine may be effective as an antiemetic.
Drug Interactions: Donepezil Possible antagonism of action
Rivastigmine Possible antagonism of action
Galantamine Possible antagonism of action
Food Interactions: Avoid alcohol.
Take with food.
Generic Name: Hydroxyzine
Synonyms: Hidroxizina [Inn-Spanish]; Hydroksyzyny [Polish]; Hydroxizinum; Hydroxyzinum [Inn-Latin]; Hydroxyzine Pamoate; Hydroxyzine Hcl; Hydroxyzine Base; Hydroxyzyne; Hydroxyzin; Hydroxycine; Idrossizina [Dcit]; Hydroxizine; Hydroxine
Drug Category: Antipruritics; Histamine H1 Antagonists; Anxiolytics sedatives and hypnotics
Drug Type: Small Molecule; Approved
Other Brand Names containing Hydroxyzine: Alamon; Atara; Atarax; Ataraxoid; Atarazoid; Atarox; Atazina; Aterax; Deinait; Durrax; Equipoise; Equipose; Fenarol; Hy-Pam 25; Hychotine; Masmoran; Neo-Calma; Neurozina; Nevrolaks; Orgatrax; Pamazone; Parenteral; Paxistil; Placidol; Plaxidol; Quiess; Tran-Q; Tranquizine; Traquizine; Vesparaz-Wirkstoff; Vistaril; Vistaril Pamoate; Vistazine;
Absorption: Rapidly absorbed from the gastrointestinal tract
Toxicity (Overdose): Oral, rat LD50: 950 mg/kg. Symptoms of overexposure include hypersedation.
Protein Binding: 93%
Biotransformation: Hepatic
Half Life: 20 to 25 hours
Dosage Forms of Ataraxoid: Capsule Oral
Syrup Oral
Liquid Intramuscular
Chemical IUPAC Name: 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol
Chemical Formula: C21H27ClN2O2
Hydroxyzine on Wikipedia: http://en.wikipedia.org/wiki/Hydroxyzine
Organisms Affected: Humans and other mammals

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