Flexyx

Flexyx drugs: Bactroban Nasal

Bactroban Nasal - General Information:

Bactroban Nasal (pseudomonic acid A, or Bactroban or Centany) is an antibiotic originally isolated from Pseudomonas fluorescens. It is used topically, and is primarily effective against Gram-positive bacteria. Bactroban Nasal is bacteriostatic at low concentrations and bactericidal at high concentrations.
Bactroban Nasal has a unique mechanism of action, which is selective binding to bacterial isoleucyl-tRNA synthetase, which halts the incorporation of isoleucine into bacterial proteins. Because this mechanism of action is not shared with any other antibiotic, mupirocin has few problems of antibiotic cross-resistance.

Related offers from our Drug Store:

Bactroban (Mupirocin) - for $56.56 Bactroban is used for the treatment of impetigo due to Staphylococcus aureus or Streptococcus pyogenes, for the treatment of infected eczema, or folliculitis (infection of the hair follicles). Bactroban is not recommended for use on the skin in serious burns, because more of the vehicle (the inactive ingredient) used for the ointment, polyethylene glycol, may be absorbed and can cause kidney damage. A nasal ointment of bactroban also is used for the elimination of nasal Staphylococcus aureus that have become resistant to other antibiotics.

* >> all this drugs based on Mupirocin (usually they can be used instead of Bactroban Nasal)

Related offer from MedStore:

Generic Bactroban (Mupirocin) - 2% 1 tube for $11.76 Bactroban (Mupirocin) is an antibacterial used to treat skin infections.

Pharmacology:

Bactroban Nasal, an antibiotic produced from Pseudomonas fluorescens, is structurally unrelated to any other topical or systemic antibiotics. Bactroban Nasal is used to treat infection caused by Staphylococcus aureus and beta-hemolytic streptococci including Streptococcus pyogenes. This antibiotic has little, if any, potential for cross-resistance with other antibiotics.

Bactroban Nasal for patients

Patients should be given the following instructions:

• Apply approximately one-half of the ointment from the single-use tube directly into one nostril and the other half into the other nostril;
• Avoid contact of the medication with the eyes;
• Discard the tube after using, do not re-use;
• Press the sides of the nose together and gently massage after application to spread the ointment throughout the inside of the nostrils; and
• Discontinue usage of the medication and call your health care practitioner if sensitization or severe local irritation occurs.

Bactroban Nasal Interactions

No information provided.

Bactroban Nasal Contraindications

This drug is contraindicated in individuals with a history of sensitivity reactions to any of its components.

Additional information about Bactroban Nasal

Bactroban Nasal Indication: For the treatment of Staphylococci nasal carriers.
Mechanism Of Action: Bactroban Nasal reversibly binds to bacterial isoleucyl-tRNA synthetase, an enzyme which promotes the conversion of isoleucine and tRNA to isoleucyl-tRNA, resulting in the inhibition of bacterial protein and RNA synthesis.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Mupirocin
Synonyms: MRC; Pseudomonic acid; Mupirocine
Where to order Mupirocin (and Bactroban Nasal analogs) online:
Drug Category: Anti-Bacterial Agents; Antibiotics
Drug Type: Small Molecule; Approved
Other Brand Names containing Mupirocin: Bactoderm; Bactroban; Bactroban Nasal; Centany; Turixin;
Absorption: No measurable systemic absorption
Toxicity (Overdose): Not Available
Protein Binding: 97%
Biotransformation: Hepatic. Following intravenous or oral administration, mupirocin is rapidly metabolized. The principal metabolite is monic acid, which has no antibacterial activity.
Half Life: 20 to 40 minutes
Dosage Forms of Bactroban Nasal: Ointment Topical
Cream Topical
Chemical IUPAC Name: 9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid
Chemical Formula: C26H44O9
Mupirocin on Wikipedia: http://en.wikipedia.org/wiki/Mupirocin
Organisms Affected: Enteric bacteria and other eubacteria