Bedix Loratadina - General Information:

A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (histamine H1 antagonists) it lacks central nervous system depressing effects such as drowsiness. [PubChem]

    Pharmacology:

    Bedix Loratadina, a non-sedating H1-blocker similar in structure to cyproheptadine and azatadine, is used to treat seasonal allergic rhinitis. Unlike other H1-blockers, loratidine does not penetrate the CNS effectively and has a low affinity for CNS H1-receptors.

    Bedix Loratadina for patients

    Description
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    This medicine is used to treat symptoms of hay fever such as runny nose,
    watery eyes and sneezing. Your doctor may use antihistimines for other
    conditions as well.

    General Information
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    This information is for educational purposes only. Not every known side
    effect, adverse effect, or drug interaction is in this database. If you
    have questions about your medicines, talk to your healthcare provider.

    Proper use of this medicine
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    For proper use of this medicine, follow the directions on the package,
    unless otherwise instructed by your doctor.

    Missed Dose
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    If your doctor has instructed you to take this medicine regularly and you
    miss a dose, take your next dose, as soon as you remember. If you are close
    to your next dose, do not double up. Skip the missed dose and go back to
    your regular schedule.

    Storage
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    Keep this medication in the container it came in, tightly closed, and out
    of reach of children. Store it at room temperature and away from excess
    heat and moisture (not in the bathroom). Throw away any medication that
    is outdated or no longer needed.

    Possible Side Effects
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    Common side effects include:
    dizzines
    drowsiness
    dry mouth
    This medicine can cause excitement especially in children.
    See a doctor immediately if you experience:
    fast or irregular heartbeat
    mental or mood changes
    tightness in the chest
    unusual tiredness or weakness.
    While taking this medicine, if you experience, chest tightness, difficulty
    in breathing or swallowing, swelling in the face or lips, go to the doctor
    immediately and stop taking the medication until you have talked to your
    doctor.

    Warnings/Precautions
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    Do NOT take this medicine with orange, apple or grapefruit juice. The levels
    of this medicine in your blood may be decreased by 70%.

    Overdose
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    Seek medical attention immediately. For non emergencies, contact your local
    or regional poison control center

    Drug Interactions
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    Before taking any other medications, by prescription or over-the-counter
    (OTC) talk to your health care provider. Some medicines may change the way
    this medicine affects your body. Also the effects of other medicines may
    be increased or decreased by this medicine.

    Pregnancy/Nursing
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    Talk to your doctor about using this medicine during pregnancy or nursing
    to discuss any possible risks to you or your baby.

    More Information
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    For more information about this medicine, talk to your healthcare provider

    Bedix Loratadina Interactions

    Loratadine (10 mg once daily) has been coadministered with therapeutic doses of erythromycin, cimetidine, and ketoconazole in controlled clinical pharmacology studies in adult volunteers. Although increased plasma concentrations (AUC 0-24 hrs) of loratadine and/or descarboethoxyloratadine were observed following coadministration of loratadine with each of these drugs in normal volunteers (n = 24 in each study), there were no clinically relevant changes in the safety profile of loratadine, as assessed by electrocardiographic parameters, clinical laboratory tests, vital signs, and adverse events. There were no significant effects on QTc intervals, and no reports of sedation or syncope. No effects on plasma concentrations of cimetidine or ketoconazole were observed. Plasma concentrations (AUC 0-24 hrs) of erythromycin decreased 15% with coadministration of loratadine relative to that observed with erythromycin alone. The clinical relevance of this difference is unknown. These above findings are summarized in TABLE 1.

    TABLE 1 Effects on Plasma Concentrations (AUC 0-24 hrs) of Loratadine and Descarboethoxyloratadine After 10 Days of Coadministration (Loratadine 10 mg) in Normal Volunteers
      Loratadine Descarboethoxyloratadine
     Erythromycin (500 mg q8h) + 40% +46%
     Cimetidine (300 mg qid) +103% + 6%
     Ketoconazole (200 mg q12h) +307% +73%


    There does not appear to be an increase in adverse events in subjects who received oral contraceptives and loratadine.

    Bedix Loratadina Contraindications

    Loratadine is contraindicated in patients who are hypersensitive to this medication or to any of its ingredients.

    Bedix Loratadina more info

    Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..