Benzhexol - General Information:

One of the centrally acting muscarinic antagonists used for treatment of parkinsonian disorders and drug-induced extrapyramidal movement disorders and as an antispasmodic. [PubChem]

Pharmacology:

Benzhexol is an anticholinergic used in the symptomatic treatment of all etiologic groups of parkinsonism and drug induced extrapyramidal reactions (except tardive dyskinesia). Benzhexol possesses both anticholinergic and antihistaminic effects, although only the former has been established as therapeutically significant in the management of parkinsonism.

Benzhexol for patients

Benzhexol Interactions

Cannabinoids, barbiturates, opiates, and alcohol may have additive effects with Trihexyphenidyl, and thus, an abuse potential exists.

Concurrent use of alcohol or other CNS depressants with Trihexyphenidyl may cause increased sedative effects.

Monoamine oxidase inhibitors and tricyclic antidepressants possessing significant anticholinergic activity may intensify the anticholinergic effects of antidyskinetic agents because of the secondary anticholinergic activities of these medications.

Prophylactic administration of anticholinergic agents, such as trihexyphenidyl, as a prevention of drug-induced parkinsonism during neuroleptic therapy is not recommended. There may be an increased risk for the development of tardive dyskinesia during concomitant administration of anticholinergics and neuroleptics.

The usual dose of either trihexyphenidyl or levodopa may need to be reduced during concomitant therapy, since concomitant administration may increase drug-induced involuntary movements.

Nursing Mothers:
It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Trihexyphenidyl is administered to a nursing woman. As with other anticholinergics, trihexyphenidyl may cause suppression of lactation. Therefore, trihexyphenidyl should only be used if the expected benefit to the mother outweighs the potential risk to the infant.

Pediatric Use:
Safety and effectiveness in pediatric patients have not been established.

Benzhexol Contraindications

ARTANE is contraindicated in patients with hypersensitivity to trihexyphenidyl HCl or to any of the tablet or elixir ingredients. Artane is also contraindicated in patients with narrow angle glaucoma. Blindness after long-term use due to narrow angle glaucoma has been reported.

Additional information about Benzhexol

Benzhexol Indication: Indicated for the treatment of parkinson's disease and extrapyramidal reactions caused by drugs.
Mechanism Of Action: Benzhexol is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral muscarinic subtypes (cardiac and glandular). Benzhexol partially blocks cholinergic activity in the CNS, which is responsible for the symptoms of Parkinson's disease. It is also thought to increase the availability of dopamine, a brain chemical that is critical in the initiation and smooth control of voluntary muscle movement.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Trihexyphenidyl
Synonyms: Trihexifenidilo [Inn-Spanish]; Trihexylphenidyl; Trihexylphenidyle; Trihexylphenizyl; Trihexyphenidyl HCl; Trihexyphenidyle; Trihexyphenidyle [Inn-French]; Trihexyphenidylum [Inn-Latin]; Triphenidyl
Drug Category: Antiparkinson Agents; Antidyskinetics
Drug Type: Small Molecule; Approved
Other Brand Names containing Trihexyphenidyl: Apo-Trihex; Artane; Artane Sequels; Benzhexol; Benzhexolum; Parkinane Retard; PMS Trihexyphenidyl; Tremin; Trihexane; Trihexy;
Absorption: Trihexyphenidyl is rapidly absorbed from the gastrointestinal tract.
Toxicity (Overdose): Symptoms of overdose include mydriasis, dryness of mucous membranes, red face, atonic states of bowels and bladder, and hyperthermia in high doses. Central consequences are agitation, confusion, and hallucinations. An untreated overdose may be fatal, particular in children. Premortal signs are respiratory depression and cardiac arrest.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: 3.3-4.1 hours
Dosage Forms of Benzhexol: Tablet Oral
Elixir Oral
Chemical IUPAC Name: 1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol
Chemical Formula: C20H31NO
Trihexyphenidyl on Wikipedia: http://en.wikipedia.org/wiki/Trihexyphenidyl
Organisms Affected: Humans and other mammals

Bookmark or Share this page


»Get link codes for this page«
(HTML/BB code)



Search by name browsing our [A-Z] index:

ABCDEFGHI
JKLMNOPQR
STUVWXYZ

Search by Categories:

See a list of all drugs for sale »

Top5 meds in current month:

*based on number of page views on Flexyx

Visit our friends:

brand and generic ed pills Russian Scientific Center for Restorative Traumatology and Orthopaedics in the name of academician G.A.Ilizarov

Related News

Fri, 28 Oct 2011
Lebanon news - NOW Lebanon - Drug use rampant in Palestinian enclave
Among the pills most used are Benzhexol, which is prescribed to lessen the effects of Parkinson's Disease, and Rivotril, which is used to treat seizures and 100 of which cost about 4,000 LL ($2.60). "These pills are disinhibiting and can provoke amnesia as well as bouts of aggression," Yaacoub said.
Source: www.nowlebanon.com »

Tue, 20 Sep 2011
Modecate Concentrate Injection 100mg/ml - Summary of Product Characteristics (SPC)
These reactions may be reduced by using smaller doses more frequently, or by the concomitant use of anti-Parkinsonian drugs such as benzhexol, benztropine or procyclidine.
Source: www.medicines.ie »

Mon, 01 Aug 2011
Pharmaceutical Benefits Scheme (PBS) - FORMULARY ALLOCATIONS - 1 August 2011
For Health Professional. FORMULARY ALLOCATIONS - 1 August 2011. Search for Medicines Search PBS info. For quality assessed information about specific conditions, diseases and treatments, please see the Health Insite website.
Source: pbs.gov.au »



Thanks for visiting us!