Binotal - General Information:

Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. [PubChem]

    Pharmacology:

    Binotal is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Binotal has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Binotal results from the inhibition of cell wall synthesis and is mediated through Binotal binding to penicillin binding proteins (PBPs). Binotal is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.

    Binotal for patients

    1. The patient should inform the physician of any history of sensitivity to allergens, including previous hypersensitivity reactions to penicillins and cephalosporins.

    2. The patient should discontinue ampicillin and contact the physician immediately if any side effect occurs.

    3. Ampicillin should be taken with a full glass (8 oz) of water, one-half hour before or two hours after meals.

    4. Diabetic patients should consult with the physician before changing diet or dosage of diabetes medication .

    Binotal Interactions

    When administered concurrently, the following drugs may interact with ampicillin.

    Allopurinol: Increased possibility of skin rash, particularly in hyperuricemic patients may occur.

    Bacteriostatic Antibiotics: Chloramphenicol, erythromycins, sulfonamides, or tetracyclines may interfere with the bactericidal effect of penicillins. This has been demonstrated in view, however, the clinical significance of this interaction is not well documented.

    Oral Contraceptives: May be less effective and increased breakthrough bleeding may occur.

    Probenecid: May decrease renal tubular secretion of ampicillin resulting in increased blood levels and/or ampicillin toxicity.

    Drug/Laboratory Test Interaction

    After treatment with ampicillin, a false-positive reaction for glucose in the urine may occur with copper sulfate tests (Benedict's solution, Fehling's solution, or Clinitest tablets) but not with enzyme based tests such as Clinistix and Glucose Enzymatic Test Strip USP.

    Binotal Contraindications

    A history of a previous hypersensitivity reaction to any of the penicillins is a contraindication. Ampicillin is also contraindicated in infections caused by penicillinase-producing organisms.

    Binotal more info

    Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..