Bismed - General Information:

Bismuth subsalicylate is the active ingredient in the popular medication Pepto-Bismol that is used to treat nausea, heartburn, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract. It is also the main ingredient of Kaopectate. It displays anti-inflammatory action (due to salicylic acid) and also acts as an antacid and mild antibiotic.

Pharmacology:

Bismuth subsalicylate displays anti-inflammatory action (due to salicylic acid) and also acts as an antacid and mild antibiotic. It can also cause a black tongue and black stools in some users of the drug, when it combines with trace amounts of sulfur in their saliva and gastrointestinal tract. This discoloration is temporary and harmless.

Additional information about Bismed

Bismed Indication: Used to treat nausea, heartburn, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract.
Mechanism Of Action: As an antidiarrheal, the exact mechanism has not been determined. Bismuth subsalicylate may exert its antidiarrheal action not only by stimulating absorption of fluid and electrolytes across the intestinal wall (antisecretory action) but also, when hydrolyzed to salicylic acid, by inhibiting synthesis of a prostaglandin responsible for intestinal inflammation and hypermotility. In addition, bismuth subsalicylate binds toxins produced by Escherichia coli. Both bismuth subsalicylate and the intestinal reaction products, bismuth oxychloride and bismuth hydroxide, are believed to have bactericidal action. As an antacid, bismuth has weak antacid properties.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Bismuth Subsalicylate
Synonyms: Bismutum subsalicylicum; Bismuthi subsalicylas; Bismuth(III) subsalicylate; Bismuth oxysalicylate; Bismuth oxide salicylate
Drug Category: Antidiarrheals
Drug Type: Small Molecule; Approved
Other Brand Names containing Bismuth Subsalicylate: Maalox multi action; Extra strength bismuth; Extra-strength bismuth; PMS-bismuth subsalicylate; Pepto-bismol; Spiromak forte; Stabisol; Vismut; Wismutsubsalicylat; Bismuth chewables; Bismuth caplets; Bismed; Bismatrol;
Absorption: Following oral administration, absorption of the salicylate component from the small intestine is generally rapid and complete (>90%).
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Based on in vitro dissociation data and in vivo animal data, bismuth subsalicylate is believed to be largely hydrolyzed in the stomach to bismuth oxychloride and salicylic acid. In the small intestine, nondissociated bismuth subsalicylate reacts with other anions (bicarbonate and phosphate) to form insoluble bismuth salts. In the colon, nondissociated bismuth subsalicylate and other bismuth salts react with hydrogen sulfide to produce bismuth sulfide, a highly insoluble black salt responsible for the darkening of the stools.
Half Life: Not Available
Dosage Forms of Bismed: Liquid Oral
Suspension Oral
Tablet Oral
Chemical IUPAC Name: 3,5-dioxa-4$l^{2}-bismabicyclo[4.4.0]deca-1(10),6,8-trien-2-one hydrate
Chemical Formula: C7H6BiO4
Bismuth Subsalicylate on Wikipedia: http://en.wikipedia.org/wiki/Bismuth_subsalicylate
Organisms Affected: Not Available

Bookmark or Share this page


»Get link codes for this page«
(HTML/BB code)



Search by name browsing our [A-Z] index:

ABCDEFGHI
JKLMNOPQR
STUVWXYZ

Search by Categories:

See a list of all drugs for sale »

Top5 meds in current month:

*based on number of page views on Flexyx

Visit our friends:

brand and generic ed pills Russian Scientific Center for Restorative Traumatology and Orthopaedics in the name of academician G.A.Ilizarov



Thanks for visiting us!