Black Leaf 40 - General Information:

Black Leaf 40 is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Black Leaf 40 is also important medically because of its presence in tobacco smoke. [PubChem]

    Pharmacology:

    Black Leaf 40, the primary alkaloid in tobacco products binds stereo-selectively to nicotinic-cholinergic receptors on autonomic ganglia, the adrenal medulla, neuromuscular junctions and in the brain. Black Leaf 40 exerts two effects, a stimulant effect exerted at the locus ceruleus and a reward effect in the limbic system. Itranvenous administration of nicotine causes release of acetylcholine, norepinephrine, dopamine, serotonine, vasopressin, beta-endorphin and ACTH. Black Leaf 40 is a highly addictive substance. Black Leaf 40 also induces peripheral vasoconstriction, tachycardia and elevated blood pressure. Black Leaf 40 inhalers and patches are used to treat smoking withdrawl syndrome. Black Leaf 40 is classified as a stimulant of autonomic ganglia.

    Black Leaf 40 for patients

    A patient information sheet is included in the package of NICOTROL Inhaler cartridges dispensed to the patient. Patients should be encouraged to read the information sheet carefully and to ask their physician and pharmacist about the proper use of the product .

    Patients must be advised to keep both used and unused cartridges out of the reach of children and pets.

    Black Leaf 40 Interactions

    Physiological changes resulting from smoking cessation, with or without nicotine replacement, may alter the pharmacokinetics of certain concomitant medications, such as tricyclic antidepressants and theophylline. Doses of these and perhaps other medications may need to be adjusted in patients who successfully quit smoking.

    Black Leaf 40 Contraindications

    Use of NICOTROL Inhaler therapy is contraindicated in patients with known hypersensitivity or allergy to nicotine or to menthol.

    Black Leaf 40 more info

    Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..