Bolvidon - General Information:

A tetracyclic compound with antidepressant effects. Bolvidon was previously available internationally, however in most markets it has been phased out in favor of Mirtazapine.

Pharmacology:

Bolvidon is a tetracyclic antidepressant that has antihistaminic and hypnosedative, but almost no anticholinergic, effect. It is a weak inhibitor of norepinephrine reuptake and strongly stimulates the release of norepinephrine. Interactions with serotonin receptors in the central nervous system have also been found. Its effect is usually noticeable after one to three weeks. Bolvidon may cause drowsiness and hematological problems.

Additional information about Bolvidon

Bolvidon Indication: For the treatment of depression.
Mechanism Of Action: Bolvidon's mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Mianserin
Synonyms: Mianseryna [polish]; Mianserinum [inn-latin]; Mianserine [inn-french]; Mianserina [inn-spanish]; Mianserine
Drug Category: Adrenergic alpha-Antagonists; Histamine H1 Antagonists; Serotonin Antagonists; Antidepressive Agents, Second-Generation
Drug Type: Small Molecule; Approved
Other Brand Names containing Mianserin: Bolvidon; Norval; Tolvan;
Absorption: Absorbed following oral administration.
Toxicity (Overdose): Oral rat LD50: 780mg/kg
Protein Binding: 90%
Biotransformation: Hepatic.
Half Life: 10-17 hours
Dosage Forms of Bolvidon: Not Available
Chemical IUPAC Name: Not Available
Chemical Formula: C18H20N2
Mianserin on Wikipedia: http://en.wikipedia.org/wiki/Mianserin
Organisms Affected: Humans and other mammals

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