Buscopan - General Information:

An alkaloid from Solanaceae, especially Datura metel L. and Scopola carniolica. Buscopan and its quaternary derivatives act as antimuscarinics like atropine, but may have more central nervous system effects. Among the many uses are as an anesthetic premedication, in urinary incontinence, in motion sickness, as an antispasmodic, and as a mydriatic and cycloplegic. [PubChem]

Pharmacology:

Buscopan is a muscarinic antagonist structurally similar to the neurotransmitter acetylcholine and acts by blocking the muscarinic acetylcholine receptors and is thus classified as an anticholinergic. Buscopan has many uses including the prevention of motion sickness. It is not clear how Buscopan prevents nausea and vomiting due to motion sickness. The vestibular part of the ear is very important for balance. When a person becomes disoriented due to motion, the vestibule sends a signal through nerves to the vomiting center in the brain, and vomiting occurs. Acetylcholine is a chemical that nerves use to transmit messages to each other. It is believe that Buscopan prevents communication between the nerves of the vestibule and the vomiting center in the brain by blocking the action of acetylcholine. Buscopan also may work directly on the vomiting center. Buscopan must be taken before the onset of motion sickness to be effective.

Buscopan for patients

Buscopan Interactions

The absorption of oral medications may be decreased during the concurrent use of scopolamine because of decreased gastric motility and delayed gastric emptying.

Scopolamine should be used with care in patients taking other drugs that are capable of causing CNS effects such as sedatives, tranquilizers, or alcohol. Special attention should be paid to potential interactions with drugs having anticholinergic properties; e.g., other belladonna alkaloids, antihistamines (including meclizine), tricyclic antidepressants, and muscle relaxants.

Laboratory Test Interactions

Scopolamine will interfere with the gastric secretion test.

Buscopan Contraindications

Transderm Scop is contraindicated in persons who are hypersensitive to the drug scopolamine or to other belladonna alkaloids, or to any ingredient or component in the formulation or delivery system, or in patients with angle-closure (narrow angle) glaucoma.

 

Additional information about Buscopan

Buscopan Indication: For the treatment of excessive salivation, colicky abdominal pain, bradycardia, sialorrhoea, diverticulitis, irritable bowel syndrome and motion sickness.
Mechanism Of Action: Buscopan acts by interfering with the transmission of nerve impulses by acetylcholine in the parasympathetic nervous system (specifically the vomiting center).
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Scopolamine
Synonyms: Not Available
Drug Category: Mydriatics; Adjuvants; Antimuscarinics; Antispasmodics
Drug Type: Small Molecule; Approved
Other Brand Names containing Scopolamine: Atrochin; Atroquin; Atroscine Hydrobromide; Beldavrin; Buscopan; Epoxytropine Tropate; Euscopol; Hydroscine Hydrobromide; Hyocine F Hydrobromide; Hyosceine; Hyoscine; Hyoscine Bromide; Hyoscine Hydrobromide; Hyoscyine Hydrobromide; Hyosol; Hysco; Isopto Hyoscine; Isoscopil; Kwells; L-Hyoscine Hydrobromide; L-Scopolamine; Methscopolamine Bromide; Oscine; SEE; Scop; Scopamin; Scopine Tropate; Scopoderm-Tts; Scopolamine Bromide; Scopolamine Hydrobromide; Scopolamine Hydrobromide Trihydrate; Scopolamine Hyoscine; Scopolaminhydrobromid; Scopolaminium Bromide; Scopolammonium Bromide; Scopos; Sereen; Skopolamin; Tranaxine; Transcop; Transderm-Scop; Transderm-V; Triptone; Tropic Acid, Ester with Scopine;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Buscopan: Solution Intravenous
Tablet Oral
Liquid Intravenous
Disc Transdermal
Solution Intramuscular
Chemical IUPAC Name: Not Available
Chemical Formula: C17H21NO4
Scopolamine on Wikipedia: http://en.wikipedia.org/wiki/Scopolamine
Organisms Affected: Humans and other mammals

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