Cobadex - General Information:

The main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. [PubChem]

    Pharmacology:

    Cobadex is the most important human glucocorticoid. It is essential for life and regulates or supports a variety of important cardiovascular, metabolic, immunologic and homeostatic functions. Topical hydrocortisone is used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic effects. Glucocorticoids are distinguished from mineralocorticoids and sex steroids by having different receptors, target cells, and effects. Technically, the term corticosteroid refers to both glucocorticoids and mineralocorticoids, but is often used as a synonym for glucocorticoid. Glucocorticoids suppress cell-mediated immunity. They act by inhibiting genes that code for the cytokines IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8 and TNF-alpha, the most important of which is the IL-2. Reduced cytokine production limits T cell proliferation. Glucocorticoids also suppress humoral immunity, causing B cells to express lower amounts of IL-2 and IL-2 receptors. This diminishes both B cell clonal expansion and antibody synthesis. The diminished amounts of IL-2 also leads to fewer T lymphocyte cells being activated.

    Cobadex for patients

    Patients using topical corticosteroids should receive the following information and instructions:

    1. This medication is to be used as directed by the physician. It is for external use only. Avoid contact with the eyes.
    2. Patients should be advised not to use this medication for any disorder other than that for which it has been prescribed.
    3. The treated skin area should not be bandaged or otherwise covered or wrapped as to be occlusive unless directed by the physician.
    4. Patients should report any signs of local adverse reactions especially under occlusive dressing.
    5. Parents of pediatric patients should be advised not to use tight-fitting diapers or plastic pants on a child being treated in the diaper area, as these garments may constitute occlusive dressings.

    Cobadex Interactions

    No information available.

    Cobadex Contraindications

    Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.

    Other Brand Names containing Hydrocortisone:

    Acticort; Aeroseb HC; Aeroseb-HC; Ala-Scalp; Ala-cort; Alacort; Algicirtis; Alphaderm; Amberin; Anflam; Anusol HC; Aquacort; Aquanil HC; Balneol-hc; Barseb HC; Basan-Corti; Beta-hc; CaldeCORT Spray; Cetacort; Clear aid; Cleiton; Cobadex; Colocort; Cortaid; Compound F; Cort-Dome; Cort-Quin; Cortanal; Cortef; Cortef Acetate; Cortenema; Cortesal; Corticreme; Cortifan; Cortifoam; Cortiment; Cortisol; Cortisol alcohol; Cortisolonum; Cortisporin; Cortisporin Otico; Cortispray; Cortolotion; Cortonema; Cortoxide; Cortril; Cremesone; Cremicort-H; Cutisol; Delacort; Derm-Aid; Dermacort; Dermaspray; Dermil; Dermocortal; Dermolate; Dioderm; Dome-cort; Domolene-HC; Dricort; Drotic; EF corlin; Efcorbin; Efcortelan; Efcortelin; Eldecort; Eldercort; Epicort; Epiderm H; Esiderm H; Evacort; Ficortril; Fiocortril; Flexicort; Foille Insetti; Genacort; Glycort; Gyno-Cortisone; H-Cort; Heb Cort; Heb-Cort; Hemsol-HC; Hi-cor; Hidalone; Hidro-Colisona; Hycort; Hycortol; Hycortole; Hydracort; Hydrasson; Hydro-adreson; Hydro-colisona; Hydrocort; Hydrocortal; Hydrocortistab; Hydrocortisyl; Hydrocortone; Hydroskin; Hysone; Hytisone; Hytone; Hytone lotion; Incortin-H; Incortin-hydrogen; Kendall's compound F; Komed HC; Kyypakkaus; Lacticare HC; Lacticare-HC; Lactisona; Locoid; Locoid Lipocream; Lubricort; Maintasone; Medicort; Meusicort; Micort-hc; Mildison; Milliderm; Neosporin-H Ear; Nogenic HC; Nutracort; Nystaform-HC; Optef; Orabase HCA; Otalgine; Otobiotic; Otocort; Otosone-F; Pandel; Pediotic Suspension; Penecort; Permicort; Polcort H; Preparation H Hydrocortisone Cream; Prepcort; Prevex HC; Proctocort; Proctofoam; Protocort; Racet; Rectoid; Reichstein's Substance M; Remederm HC; Sanatison; Scalpicin Capilar; Schericur; Scheroson F; Sigmacort; Signef; Stie-cort; Stiefcorcil; Synacort; Systral Hydrocort; THE; Tarcortin; Tetrahydro E; Tetrahydrocompound E; Texacort; Texacort lotion 25; Thyrotropic-releasing factor; Timocort; Transderma H; Traumaide; Uniderm; Urocortisone; Vioform-Hydrocortisone; VoSol HC; Vytone; Westcort; Zenoxone;

    Cobadex more info

    Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..