Flexyx

Flexyx drugs: Cocaine

Cocaine - General Information:

An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake. [PubChem]

Pharmacology:

Cocaine is a local anesthetic indicated for the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities.

Cocaine for patients

Cocaine Interactions

No information provided.

Cocaine Contraindications

Cocaine Hydrochloride is contraindicated in patients with a known history of hypersensitivity to the drug or to the components of the solution.

Additional information about Cocaine

Cocaine Indication: For the introduction of local (topical) anesthesia of accessible mucous membranes of the oral, laryngeal and nasal cavities.
Mechanism Of Action: Cocaine produces anesthesia by inhibiting excitation of nerve endings or by blocking conduction in peripheral nerves. This is achieved by reversibly binding to and inactivating sodium channels. Sodium influx through these channels is necessary for the depolarization of nerve cell membranes and subsequent propagation of impulses along the course of the nerve. Cocaine is the only local anesthetic with vasoconstrictive properties. This is a result of its blockade of norepinephrine reuptake in the autonomic nervous system. Cocaine binds differentially to the dopamine, serotonin, and norepinephrine transport proteins and directly prevents the re-uptake of dopamine, serotonin, and norepinephrine into pre-synaptic neurons. Cocaine also produces a number of indirect actions, which alter other neuromodulatory systems (i.e., opioidergic, glutamatergic, and GABAergic systems).
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Cocaine
Synonyms: Benzoylethylecgonine; Bazooka; Badrock; Benzoylmethylecgonine; Bernice; Bernies; Beta-Cocain; Blast; Blizzard; Blow; Bouncing Powder; Bump; Burese; C" Carrie; Cocaine Free Base; Cocaina; Cocaine-M; Cocain; Coca; COC; Cholly; Chicken Scratch; Charlie; Cecil; Caviar; Carrie; Candy; Cabello; Dextrocaine; Depsococaine; Delcaine; Dama Blanca; D-pseudococaine; Corine; Cola; Coke; Cocktail; Zip; Yeyo; Trails; Toot; Toke; Sweet Stuff; Sugar; Star-Spangled Powder; Star Dust; Snort; Sleighride; Rock; Prime Time; Pimp's Drug; Neurocaine; Moonrocks; Methyl Benzoylecgonine; Line; Leaf; Lady; L-Cocaine; L-Cocain; Kokayeen; Kokan; Kokain; Kibbles N' Bits; Jam; Isococaine; Isococain; Isocaine; Hell; Heaven; Happy Trails; Happy Powder; Happy Dust; Green Gold; Goofball; Gold Dust; Girl; G-Rock; Freeze; Foo Foo; Florida Snow; Flex; Flake; Erytroxylin; Eritroxilina; Dust
Drug Category: Vasoconstrictor Agents; Anesthetics; Local Anesthetics
Drug Type: Small Molecule; Illicit; Approved
Other Brand Names containing Cocaine: Cocaine;
Absorption: Cocaine is absorbed from all sites of application, including mucous membranes and gastrointestinal mucosa. By oral or intra-nasal route, 60 to 80% of cocaine is absorbed.
Toxicity (Overdose): Intense agitation, convulsions, hypertension, rhythm disturbance, coronary insufficiency, hyperthermia, rhabdomyolysis, and renal impairment. Oral mouse LD₅₀ = 96 mg/kg
Protein Binding: Not Available
Biotransformation: Hepatic. Cocaine is metabolized to benzoylecgonine and ecgonine methyl ester, which are both excreted in the urine. In the presence of alcohol, a further active metabolite, cocaethylene is formed, and is more toxic then cocaine itself.
Half Life: 1 hour
Dosage Forms of Cocaine: Liquid Topical
Chemical IUPAC Name: methyl (2R,3S)-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
Chemical Formula: C17H21NO4
Cocaine on Wikipedia: http://en.wikipedia.org/wiki/Cocaine
Organisms Affected: Humans and other mammals