Cocculus - General Information:

A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Cocculus blocks the gamma-aminobutyric acid-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates. [PubChem]

    Pharmacology:

    Cocculus is a toxin obtained from the seeds of the shrub Anamirta cocculus. It is used as a central nervous system stimulant, antidote, convulsant, and GABA (gamma aminobutyric acid) antagonist. It is a noncompetitive antagonist at GABAA receptors and thus a convulsant. Cocculus blocks the GABAActivated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially barbiturates.

    Other Brand Names containing Picrotoxin:

    Cocculin; Cocculine; Cocculus; Coques du levant; Fish berry; Indian berry; Oriental berry;

    Cocculus more info

    Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..