Flexyx

Flexyx drugs: Colo-Pleon

Colo-Pleon - General Information:

A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see mesalamine) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)


Related offers from our Drug Store:

Azulfidine (Sulfasalazine) - for $44.75 Azulfidine is used for the treatment of mild to moderate ulcerative colitis; as adjunctive therapy (i.e. with other medications) in the treatment of severe ulcerative colitis; for the treatment of Crohn's disease; for the treatment of rheumatoid arthritis or ankylosing spondylitis.

* >> all this drugs based on Sulfasalazine (usually they can be used instead of Colo-Pleon)

Pharmacology:

Colo-Pleon is an anti-inflammatory indicated for the treatment of ulcerative colitis and rheumatoid arthritis.

Colo-Pleon for patients

Colo-Pleon Interactions

Reduced absorption of folic acid and digoxin have been reported when those agents were administered concomitantly with sulfasalazine.

When daily doses of sulfasalazine 2 g and weekly doses of methotrexate 7.5 mg were coadministered to 15 rheumatoid arthritis patients in a drug-drug interaction study, the pharmacokinetic disposition of the drugs was not altered.

Daily doses of sulfasalazine 2 g (maximum 3 g) and weekly doses of methotrexate 7.5 mg (maximum 15 mg) were administered alone or in combination to 310 rheumatoid arthritis patients in two controlled 52-week clinical studies. The overall toxicity profile of the combination revealed an increased incidence of gastrointestinal adverse events, especially nausea, when compared to the incidence associated with either drug administered alone.

Drug/Laboratory Test Interactions: The presence of sulfasalazine or its metabolites in body fluids has not been reported to interfere with laboratory test procedures.

REFERENCES

7.Farr M, et al. Immunodeficiencies associated with sulphasalazine therapy in inflammatory arthritis. British Jnl Rheum 1991;30:413-417.

 

Colo-Pleon Contraindications

AZULFIDINE EN-tabs Tablets are contraindicated in:

Hypersensitivity to sulfasalazine, its metabolites, sulfonamides or salicylates,

Patients with intestinal or urinary obstruction,

Patients with porphyria, as the sulfonamides have been reported to precipitate an acute attack.

Additional information about Colo-Pleon

Colo-Pleon Indication: For the treatment of Crohn's disease and rheumatoid arthritis as a second-line agent.
Mechanism Of Action: The mode of action of Colo-Pleon or its metabolites, 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP), is still under investigation, but may be related to the anti-inflammatory and/or immunomodulatory properties that have been observed in animal and in vitro models, to its affinity for connective tissue, and/or to the relatively high concentration it reaches in serous fluids, the liver and intestinal walls, as demonstrated in autoradiographic studies in animals. In ulcerative colitis, clinical studies utilizing rectal administration of Colo-Pleon, SP and 5-ASA have indicated that the major therapeutic action may reside in the 5-ASA moiety. The relative contribution of the parent drug and the major metabolites in rheumatoid arthritis is unknown.
Drug Interactions: Not Available
Food Interactions: Take with food.
Take with a full glass of water No iron, zinc or fluoride within 2 hours of taking this medication.
May take Vitamin D.
Generic Name: Sulfasalazine
Synonyms: Sulphasalazine; Sulfasalazin
Where to order Sulfasalazine (and Colo-Pleon analogs) online:
Drug Category: Antirheumatic Agents; Gastrointestinal Agents; Sulfonamides; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal
Drug Type: Small Molecule; Approved
Other Brand Names containing Sulfasalazine: Accucol; Alti-Sulfasalazine; Asulfidine; Azlufidine EN-Tabs; Azopyrin; Azopyrine; Azulfidine; Azulfidine EN-Tabs; Benzosulfa; Colo-Pleon; PMS-Sulfasalazine; Pms-Sulfasalazine E.C.; Reupirin; Rorasul; S.A.S. Enteric-500; Salazopiridazin; Salazopyridin; Salazopyrin; Salazopyrin EN-Tabs; Salazosulfapyridin; Salazosulfapyridine; Salicylazosulfapyridine; Salisulf; Sulcolon; W-T Sasp Oral;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: 5-10 hours
Dosage Forms of Colo-Pleon: Tablet Oral
Tablet, coated Oral
Chemical IUPAC Name: (3E)-6-oxo-3-[[4-(pyridin-2-ylsulfamoyl)phenyl]hydrazinylidene]cyclohexa-1,4-diene-1-carboxylic acid
Chemical Formula: C18H14N4O5S
Sulfasalazine on Wikipedia: http://en.wikipedia.org/wiki/Sulfasalazine
Organisms Affected: Humans and other mammals