Corotrope - General Information:A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase activity in myocardium and vascular smooth muscle. Corotrope is a derivative of amrinone and has 20-30 times the ionotropic potency of amrinone. [PubChem]
Pharmacology:Corotrope, a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine, is used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.
Corotrope for patients
No untoward clinical manifestations have been observed in limited experience with patients in whom PRIMACOR was used concurrently with the following drugs: digitalis glycosides; lidocaine, quinidine; hydralazine, prazosin; isosorbide dinitrate, nitroglycerin; chlorthalidone, furosemide, hydrochlorothiazide, spironolactone; captopril; heparin, warfarin, diazepam, insulin; and potassium supplements.
There is an immediate chemical interaction which is evidenced by the formation of a precipitate when furosemide is injected into an intravenous line of an infusion of PRIMACOR. Therefore, furosemide should not be administered in intravenous lines containing PRIMACOR.
PRIMACOR is contraindicated in patients who are hypersensitive to it.
Additional information about CorotropeCorotrope Indication: Indicated for the treatment of congestive heart failure.
Mechanism Of Action: Corotrope inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, Corotrope also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Milrinone
Synonyms: Milrinone Lactate
Drug Category: Vasodilator Agents; Cardiotonic Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Milrinone: Corotrop; Corotrope; Milrila; Primacor;
Absorption: Milrinone is rapidly and almost completely absorbed after oral administration. Bioavailability is 92% (in healthy volunteers).
Toxicity (Overdose): LD50 = 0.3 mg/L in rats
Protein Binding: 70 to 80%
Biotransformation: There are five metabolites but the O-glucuronide represents the major pathway of biotransformation.
Half Life: 2.3 hours
Dosage Forms of Corotrope: Solution Intravenous
Chemical IUPAC Name: 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
Chemical Formula: C12H9N3O
Milrinone on Wikipedia: http://en.wikipedia.org/wiki/Milrinone
Organisms Affected: Humans and other mammals
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