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Cyclapen-W - General Information: A cyclohexylamido analog of penicillanic acid. [PubChem] Pharmacology: Cyclapen-W, a penicillin, is a cyclohexylamido analog of penicillanic acid. Cyclapen-W is more resistant to beta-lactamase hydrolysis than ampicillin, is much better absorbed when given by mouth and, as a result, the levels reached in the blood and in the urine are considerably higher than those obtained with the same dose of ampicillin. Cyclapen-W has been replaced by newer penicillin treatments. Additional information about Cyclapen-WCyclapen-W Indication: For the treatment of bacterial infections caused by susceptible organisms. Mechanism Of Action: The bactericidal activity of cyclacillin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Cyclapen-W is stable in the presence of a variety of b-lactamases, including penicillinases and some cephalosporinases. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Cyclacillin Synonyms: Ciclacilline [INN-French]; Ciclacillinum [INN-Latin]; Ciclacilina [INN-Spanish]; Aminocyclohexylpenicillin; Ciclacillin; Ciclacillum Where to order Cyclacillin (and Cyclapen-W analogs) online: Drug Category: Anti-Bacterial Agents Drug Type: Small Molecule; Approved Other Brand Names containing Cyclacillin: Bastcillin; Calthor; Citosarin; Cyclapen; Cyclapen-W; Orfilina; Syngacillin; Ultracillin; Vastcillin; Vipicil; Wyvital; Absorption: Moderately absorbed. Toxicity (Overdose): Symptoms of overdose include severe diarrhea, nausea and vomiting. Protein Binding: Not Available Biotransformation: Not Available Half Life: Not Available Dosage Forms of Cyclapen-W: Not Available Chemical IUPAC Name: (2S,5R,6R)-6-[(1-aminocyclohexanecarbonyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical Formula: C15H23N3O4S Cyclacillin on Wikipedia: Not Available Organisms Affected: Enteric bacteria and other eubacteria
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