Cyclobenz - General Information:

Cyclobenz is a skeletal muscle relaxant and a central nervous system (CNS) depressant. Cyclobenz acts on the locus coeruleus where it results in increased norepinephrine release, potentially through the gamma fibers which innervate and inhibit the alpha motor neurons in the ventral horn of the spinal cord. It is structurally similar to Amitriptyline, differing by only one double bond.

    Pharmacology:

    Cyclobenz, closely related to the antidepressant amitriptyline, is used as a skeletal muscle relaxant to reduce pain and tenderness and improve mobility. Unlike dantrolene, cyclobenzaprine cannot be used to treat muscle spasm secondary to cerebral or spinal cord disease.

    Cyclobenz for patients

    FLEXERIL, especially when used with alcohol or other CNS depressants, may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle. In the elderly, the frequency and severity of adverse events associated with the use of cyclobenzaprine, with or without concomitant medications, is increased. In elderly patients, FLEXERIL should be initiated with a 5 mg dose and titrated slowly upward.

    Cyclobenz Interactions

    FLEXERIL may have life-threatening interactions with MAO inhibitors.

    FLEXERIL may enhance the effects of alcohol, barbiturates, and other CNS depressants.

    Tricyclic antidepressants may block the antihypertensive action of guanethidine and similarly acting compounds.

    Tricyclic antidepressants may enhance the seizure risk in patients taking tramadol.

     

    Cyclobenz Contraindications

    Hypersensitivity to any component of this product.

    Concomitant use of monoamine oxidase (MAO) inhibitors or within 14 days after their discontinuation. Hyperpyretic crisis seizures, and deaths have occurred in patients receiving cyclobenzaprine (or structurally similar tricyclic antidepressants) concomitantly with MAO inhibitor drugs.

    Acute recovery phase of myocardial infarction, and patients with arrhythmias, heart block or conduction disturbances, or congestive heart failure.

    Hyperthyroidism.

    Other Brand Names containing Cyclobenzaprine:

    Cyclobenz; Flexeril; Flexiban; Proeptatriene; Proheptatriene;

    Cyclobenz more info

    Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..