Flexyx

Flexyx drugs: Declinax

Declinax - General Information:

An adrenergic neuron-blocking drug similar in effects to guanethidine. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism. [PubChem]

Pharmacology:

Declinax is an adrenergic neuron-blocking drug similar in effects to guanethidine. It is a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.

Additional information about Declinax

Declinax Indication: For the treatment of moderate and severe hypertension, either alone or as an adjunct, and for the treatment of renal hypertension.
Mechanism Of Action: Declinax acts at the sympathetic neuroeffector junction by inhibiting or interfering with the release and/or distribution of norepinephrine, rather than acting at the effector cell by inhibiting the association of norepinephrine with its receptors. In contrast to ganglionic blocking agents, debrisoquin suppresses equally the responses mediated by alpha-and beta-adrenergic receptors but does not produce parasympathetic blockade. Since sympathetic blockade results in modest decreases in peripheral resistance and cardiac output, debrisoquin lowers blood pressure in the supine position. It further reduces blood pressure by decreasing the degree of vasoconstriction that normally results from reflex sympathetic nervous activity upon assumption of the upright posture, thus reducing venous return and cardiac output more.
Drug Interactions: Not Available
Food Interactions: Take without regard to meals.
Generic Name: Debrisoquin
Synonyms: Debrisochinum; Debrisoquin hemisulfate; Debrisoquin sulfate; Debrisoquina [inn-spanish]; Debrisoquine; Debrisoquine sulfate; Debrisoquinum [inn-latin]; Isocaramidine; Isocaramidine sulfate
Where to order Debrisoquin (and Declinax analogs) online:
Drug Category: Adrenergic Agents; Antihypertensive Agents; Sympatholytics
Drug Type: Small Molecule; Approved
Other Brand Names containing Debrisoquin: Declinax; Equitonil; Tendor;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Hepatic.
Half Life: Not Available
Dosage Forms of Declinax: Not Available
Chemical IUPAC Name: 3,4-dihydro-1H-isoquinoline-2-carboximidamide
Chemical Formula: C10H13N3
Debrisoquin on Wikipedia: Not Available
Organisms Affected: Humans and other mammals