Dilaudid - General Information:An opioid analgesic made from morphine and used mainly as an analgesic. It has a shorter duration of action than morphine. [PubChem]
Other Brand Names containing Hydromorphone
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Dilaudid - Pharmacology:
Dilaudid is a narcotic analgesic; its principal therapeutic effect is relief of pain. Dilaudid interacts predominantly with the opioid mu-receptors. These mu-binding sites are discretely distributed in the human brain, with high densities in the posterior amygdala, hypothalamus, thalamus, nucleus caudatus, putamen, and certain cortical areas. They are also found on the terminal axons of primary afferents within laminae I and II (substantia gelatinosa) of the spinal cord and in the spinal nucleus of the trigeminal nerve. In clinical settings, Dilaudid exerts its principal pharmacological effect on the central nervous system and gastrointestinal tract. Dilaudid also binds with kappa-receptors which are thought to mediate spinal analgesia, miosis and sedation.
Dilaudid for patients
Patients receiving other narcotic analgesics, general anesthetics, phenothiazines, tranquilizers, sedative-hypnotics, tricyclic antidepressants or other CNS depressants (including alcohol) concomitantly with DILAUDID may exhibit an additive CNS depression. When such combined therapy is contemplated, the dose of one or both agents should be reduced.
DILAUDID is contraindicated in patients with a known hypersensitivity to hydromorphone; in the presence of an intracranial lesion associated with increased intracranial pressure; and whenever ventilatory function is depressed (chronic obstructive pulmonary disease, cor pulmonale, emphysema, kyphoscoliosis, status asthmaticus).
Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..