Flexyx

Flexyx drugs: Diovan HCT

Diovan HCT - General Information:

Diovan HCT (trade name Diovan®) is an angiotensin II receptor antagonist, acting on the AT1 subtype. In the U.S., valsartan is indicated for treatment of high blood pressure, of congestive heart failure (CHF), and post-myocardial infarction (MI). In 2005, Diovan® was prescribed more than 12 million times in the United States.

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Diovan (Valsartan) - for $40.68 Diovan is used to treat high blood pressure and heart failure. It is also prescribed after heart attacks since diovan may reduce death in patients who developed congestive heart failure after a heart attack. Diovan may also reduce hospitalizations in patients with congestive heart failure.

* >> all this drugs based on Valsartan (usually they can be used instead of Diovan HCT)

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Generic Diovan (Valsartan) - 80mg 30 pills for $23.70 Diovan (Valsartan) is an angiotensin II receptor antagonist used to treat high blood pressure. It may also be used to treat congestive heart failure and other conditions as determined by your doctor.

Pharmacology:

Diovan HCT, a specific angiotensin II antagonist, is used alone or with other antihypertensive agents to treat hypertension. Unlike the angiotensin receptor antagonist losartan, Diovan HCT does not have an active metabolite or possess uricosuric effects.

Diovan HCT for patients

Diovan HCT Interactions

No clinically significant pharmacokinetic interactions were observed when valsartan was coadministered with amlodipine, atenolol, cimetidine, digoxin, furosemide, glyburide, hydrochlorothiazide, or indomethacin. The valsartan-atenolol combination was more antihypertensive than either component, but it did not lower the heart rate more than atenolol alone.

Coadministration of valsartan and warfarin did not change the pharmacokinetics of valsartan or the time-course of the anticoagulant properties of warfarin.

CYP 450 Interactions: The enzyme(s) responsible for valsartan metabolism have not been identified but do not seem to be CYP 450 isozymes. The inhibitory or induction potential of valsartan on CYP 450 is also unknown.

As with other drugs that block angiotensin II or its effects, concomitant use of potassium sparing diuretics (e.g. spironolactone, triamterene, amiloride), potassium supplements, or salt substitutes containing potassium may lead to increases in serum potassium and in heart failure patients to increases in serum creatinine.

Diovan HCT Contraindications

Diovan^® (valsartan) is contraindicated in patients who are hypersensitive to any component of this product.

Additional information about Diovan HCT

Diovan HCT Indication: For the treatment of hypertension.
Mechanism Of Action: Diovan HCT competes with angiotensin II for binding at the AT₁ receptor subtype. As angiotensin II is a vasoconstrictor which also stimulates the synthesis and release of aldosterone, blockage of its effects results in a decreases in systemic vascular resistance.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Valsartan
Synonyms: Not Available
Where to order Valsartan (and Diovan HCT analogs) online: Generic Diovan - Valsartan (on DrugsPill.com)
Drug Category: Antihypertensive Agents; Angiotensin II Receptor Antagonists
Drug Type: Small Molecule; Approved; Investigational
Other Brand Names containing Valsartan: Diovan; Diovan HCT; Valsarran;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: 95%
Biotransformation: Not Available
Half Life: 6 hours
Dosage Forms of Diovan HCT: Tablet Oral
Capsule Oral
Chemical IUPAC Name: (2S)-3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid
Chemical Formula: C24H29N5O3
Valsartan on Wikipedia: http://en.wikipedia.org/wiki/Valsartan
Organisms Affected: Humans and other mammals