Enisyl - General Information:

Enisyl (abbreviated as Lys or K)[1] is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG.
Enisyl is a base, as are arginine and histidine. The ε-amino group often participates in hydrogen bonding and as a general base in catalysis. Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell.

Pharmacology:

Insures the adequate absorption of calcium; helps form collagen ( which makes up bone cartilage & connective tissues); aids in the production of antibodies, hormones & enzymes. Recent studies have shown that Lysine may be effective against herpes by improving the balance of nutrients that reduce viral growth. A deficiency may result in tiredness, inability to concentrate, irritability, bloodshot eyes, retarded growth, hair loss, anemia & reproductive problems.

Enisyl for patients

Pregnant women and nursing mothers should only consider using supplemental L-lysine if their diets are low in this amino acid. They should avoid supplemental L-lysine for other reasons. Proteins such as casein, which are high in L-lysine relative to L-arginine, are associated with elevated cholesterol levels. Those with hypercholesterolemia who are interested in taking supplemental L-lysine should be aware of this. Those with hepatic or renal failure should exercise caution in the use of supplemental L-lysine.

Enisyl Interactions

Concomitant use of calcium supplements and L-lysine may increase calcium absorption

Enisyl Contraindications

L-lysine supplementation is contraindicated in those with the rare genetic disorder hyperlysinemia/hyperlysinuria.

Additional information about Enisyl

Enisyl Indication: Supplemental L-lysine has putative anti-herpes simplex virus activity. There is preliminary research suggesting that it may have some anti-osteoporotic activity.
Mechanism Of Action: Proteins of the herpes simplex virus are rich in L-arginine, and tissue culture studies indicate an enhancing effect on viral replication when the amino acid ratio of L-arginine to L-lysine is high in the tissue culture media. When the ratio of L-lysine to L-arginine is high, viral replication and the cytopathogenicity of herpes simplex virus have been found to be inhibited. L-lysine may facilitate the absorption of calcium from the small intestine.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: L-Lysine
Synonyms: 2,6-diaminohexanoic acid; L-lys; LYS; lysine; lysine acid
Drug Category: Dietary supplement; Micronutrient; Essential Amino Acids
Drug Type: Small Molecule; Nutraceutical; Approved
Other Brand Names containing L-Lysine: Enisyl;
Absorption: Absorbed from the lumen of the small intestine into the enterocytes by an active transport process
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Hepatic
Half Life: Not Available
Dosage Forms of Enisyl: Not Available
Chemical IUPAC Name: (2S)-2,6-diaminohexanoic acid
Chemical Formula: C6H14N2O2
L-Lysine on Wikipedia: http://en.wikipedia.org/wiki/L-Lysine
Organisms Affected: Humans and other mammals

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