Flexyx

Flexyx drugs: Epogen (Amgen Inc.)

Epogen (Amgen Inc.) - General Information:

Human erythropoietin (recombinant), produced by CHO cells.

Pharmacology:

Used in the treatment of anemia. Involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass.

Epogen (Amgen Inc.) for patients

Epogen (Amgen Inc.) Interactions

No evidence of interaction of PROCRIT with other drugs was observed in the course of clinical trials.  

Epogen (Amgen Inc.) Contraindications

PROCRIT is contraindicated in patients with:  

1. Uncontrolled hypertension

2. Known hypersensitivity to mammalian cell-derived products

3. Known hypersensitivity to Albumin (Human)

 

Additional information about Epogen (Amgen Inc.)

Epogen (Amgen Inc.) Indication: For treatment of anemia (from renal transplants or certain HIV treatment)
Mechanism Of Action: Binding of erythropoietin to the erythropoietin receptor leads to receptor dimerization, which facilitates activation of JAK-STAT signaling pathways within the cytosol. Activated STAT (signal transducers and activators of transcription) proteins are then translocated to the nucleus where they serve as transcription factors which regulate the activation of specific genes involved in cell division or differentiation.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Epoetin alfa
Synonyms: Epoetin; Erythropoietin precursor
Drug Category: Antianemic Agents
Drug Type: Biotech; Approved
Other Brand Names containing Epoetin alfa: Epogen (Amgen Inc.); Epogin (Chugai); Epomax (Elanex); Eprex (Janssen-Cilag. Ortho Biologics LLC); NeoRecormon (Roche); Procrit (Ortho Biotech); Recormon (Roche);
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Epogen (Amgen Inc.): Liquid Subcutaneous
Solution Subcutaneous
Solution Intravenous
Chemical IUPAC Name: Human erythropoietin
Chemical Formula: C815H1317N233O241S5
Epoetin alfa on Wikipedia: http://en.wikipedia.org/wiki/Epoetin_alfa
Organisms Affected: Humans and other mammals