Fenilep - General Information:Fenilep is used to control certain seizures in the treatment of epilepsy. This medicine acts on the central nervous system (CNS) to reduce the number and severity of seizures.
Pharmacology:Fenilep is a ureal anticonvulsant indicated for control of severe epilepsy, particularly mixed forms of complex partial (psychomotor or temporal lobe) seizures, refractory to other anticonvulsants. Fenilep elevates the threshold for minimal electroshock convulsions and abolishes the tonic phase of maximal electroshock seizures. It also prevents or modifies seizures induced by pentylenetetrazol or other convulsants.
Additional information about FenilepFenilep Indication: Used to control certain seizures in the treatment of epilepsy.
Mechanism Of Action: Fenilep binds to and blocks neuronal sodium channels or voltage sensitive calcium channels. This blocks or suppresses neuronal depolarization and hypersynchronization. Hypersynchronization is what often causes seizures.
Drug Interactions: Not Available
Food Interactions: May be taken with food if stomach upset occurs.
Generic Name: Phenacemide
Synonyms: Carbamide phenylacetate; PA; Phenacetylcarbamide; Phenacetylurea; Phenylacetylurea; Phenylacetyluree
Drug Category: Anticonvulsants
Drug Type: Small Molecule; Approved
Other Brand Names containing Phenacemide: Acetylureum; Carbanmide; Cetylureum; Comitiadone; Eferon; Efron; Epheron; Epiclase; Felurea; Fenacemid; Fenacemide; Fenacetamide; Fenacetil-Karbamide; Fenilep; Fenised; Fenostenyl; Fenural; Fenurea; Fenurone; Fenylacetylmocovina; Fenytan; Neophedan; Neophenal; Phacetur; Phenacalum; Phenacereum; Phenacetur; Phenarone; Phenicarb; Phenuron; Phenurone; Phenutal; Phenyrit; Phetylureum;
Absorption: Almost completely absorbed.
Toxicity (Overdose): Oral, mouse: LD50 = 987 mg/kg; Oral, rabbit: LD50 = 2500 mg/kg; Oral, rat: LD50 = 1600 mg/kg
Protein Binding: Not Available
Biotransformation: Metabolized in the liver by hepatic microsomal enzymes, where it is inactivated by p-hydroxylation.
Half Life: 22-25 hours.
Dosage Forms of Fenilep: Tablet Oral
Chemical IUPAC Name: N-carbamoyl-2-phenylacetamide
Chemical Formula: C9H10N2O2
Phenacemide on Wikipedia: http://en.wikipedia.org/wiki/Phenacemide
Organisms Affected: Humans and other mammals
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