Flexal - General Information:

A centrally acting skeletal muscle relaxant whose mechanism of action is not completely understood but may be related to its sedative actions. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1202)

Pharmacology:

Flexal is used as a skeletal muscle relaxant. One of its metabolites, meprobamate, is available as an anxiolytic agent.

Flexal for patients

Carisoprodol is a muscle relaxant used to relieve the pain and stiffness of muscle spasms and discomfort due to strain and sprain. Inform your physician if you are pregnant or nursing. Do not take this medication with a monoamine oxidase inhibitor. This medication may cause dizziness, drowsiness, or blurred vision; use caution while driving or operating hazardous machinery. Do not take any other sedating drugs or drink alcohol while taking carisoprodol. If dizziness occurs, avoid sudden changes in posture. Take this medication with food to avoid stomach upset. Notify your physician if you develop trouble breathing, unexplained fever, severe weakness, vision changes, swelling, or skin rash. Withdrawal symptoms may occur if therapy is suddenly stopped in a patient on long-term or high-dose therapy.

Flexal Interactions

No information provided.

Flexal Contraindications

Acute intermittent porphyria as well as allergic or idiosyncratic reactions to carisoprodol or related compounds, such as meprobamate, mebutamate, or tybamate.

Additional information about Flexal

Flexal Indication: For the relief of discomfort associated with acute, painful, musculoskeletal conditions.
Mechanism Of Action: The mechanism of action is not known. Rather than acting directly on skeletal muscle, carisoprodol interrupts neuronal communication within the reticular formation and spinal cord, resulting in sedation and alteration in pain perception.
Drug Interactions: Not Available
Food Interactions: Take without regard to meals.
Avoid alcohol.
Generic Name: Carisoprodol
Synonyms: Isoprothane; Isoprotane; Isomeprobamate; Carisoprodatum; Carisoprodate
Drug Category: Muscle Relaxants; Skeletal Muscle Relaxants
Drug Type: Small Molecule; Approved
Other Brand Names containing Carisoprodol: Artifar; Caridolin; Chinchen; Fibrosona; Flexagilt; Flexagit; Flexidon; Listaflex; Meprodat; Muslax; Neotica; Scutamil-C; Skutamil; Soma; Carisoma; Mioartrina; Miolisodal; Mioratrina; Flexartal; Atonalyt; Nospasm; Relasom; Somanil; Apesan; Arusal; Flexal; Mioril; Sanoma;
Absorption: Not Available
Toxicity (Overdose): Symptoms of overdose include drowsiness, giddiness, nausea, indigestion, or rash. Other adverse effects attributed to therapeutic use of carisoprodol include dizziness, irritability, insomnia, diplopia, temporary loss of vision, ataxia, weakness, headache, and dysarthria. Non-CNS adverse effects include gastrointestinal complaints, tachycardia, and postural hypotension. Patients sensitive to sulfites or tartrazine may experience wheezing, allergic rashes including erythema multiforme, or anaphylaxis after using some preparations of carisoprodol which contain such additives
Protein Binding: 60%
Biotransformation: Hepatic. Metabolized in the liver via the cytochrome P450 oxidase isozyme CYP2C19.
Half Life: 8 hours
Dosage Forms of Flexal: Tablet Oral
Chemical IUPAC Name: [2-(carbamoyloxymethyl)-2-methylpentyl] N-propan-2-ylcarbamate
Chemical Formula: C12H24N2O4
Carisoprodol on Wikipedia: http://en.wikipedia.org/wiki/Carisoprodol
Organisms Affected: Humans and other mammals

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