Flexyx

Flexyx drugs: Flixonase

Flixonase - General Information:

Fluticasone propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma.




Related offers from our Drug Store:

	Flonase (Fluticasone Propionate) - for $62.65 Flonase is used for treatment of allergic and non-allergic nasal symptoms including congestion, sneezing, itching, and runny nose.
	Flovent (Fluticasone Propionate) - for $62.65 Flovent Spray is used for treatment of allergic and non-allergic nasal symptoms including congestion, sneezing, itching, and runny nose.

* >> all this drugs based on Fluticasone Propionate (usually they can be used instead of Flixonase)

Related offer from MedStore:

Generic Advair Diskus (Fluticasone / Salmeterol) - 100/50mcg 1 accuhaler for $86.40 Fluticasone is a steroid. It prevents the release of substances in the body that cause inflammation. Salmeterol is a bronchodilator. It works by relaxing muscles in the airways to improve breathing. Advair Diskus (Fluticasone and Salmeterol) inhalation is used to prevent asthma attacks. It is also used to prevent flare-ups or worsening of chronic obstructive pulmonary disease (COPD) associated with chronic bronchitis and/or emphysema.

Pharmacology:

Fluticasone propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma.

Flixonase for patients

Flixonase Interactions

No Information Provided.

Flixonase Contraindications

CUTIVATE Cream is contraindicated in those patients with a history of hypersensitivity to any of the components in the preparation.

Additional information about Flixonase

Flixonase Indication: For the maintenance treatment of asthma as prophylactic therapy and for patients requiring oral corticosteroid therapy for asthma.
Mechanism Of Action: Binds to the glucocorticoid receptor. Unbound corticosteroids cross the membranes of cells such as mast cells and eosinophils, binding with high affinity to glucocorticoid receptors (GR). The results include alteration of transcription and protein synthesis, a decreased release of leukocytic acid hydrolases, reduction in fibroblast proliferation, prevention of macrophage accumulation at inflamed sites, reduction of collagen deposition, interference with leukocyte adhesion to the capillary wall, reduction of capillary membrane permeability and subsequent edema, reduction of complement components, inhibition of histamine and kinin release, and interference with the formation of scar tissue. In the management of asthma, the glucocorticoid receptor complexes down-regulates proinflammatory mediators such as interleukin-(IL)-1, 3, and 5, and up-regulates anti-inflammatory mediators such as IkappaB [inhibitory molecule for nuclear factor kappaB1], IL-10, and IL-12. The antiinflammatory actions of corticosteroids are also thought to involve release of cytosolic phospholipase A2 which controls the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Fluticasone Propionate
Synonyms: Not Available
Drug Category: Anti-Allergic Agents; Dermatologic Agents; Bronchodilator Agents; Anti-inflammatory Agents; Adrenergic Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Fluticasone Propionate: Advair Diskus 100/50; Advair Diskus 250/50; Advair Diskus 500/50; Cutivate; Flixonase; Flixotide; Flonase; Flovent; Flovent Diskus 100; Flovent Diskus 250; Flovent Diskus 50; Flovent HFA; Flunase;
Absorption: The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier.
Toxicity (Overdose): Not Available
Protein Binding: 91%
Biotransformation: Fluticasone propionate is metabolized in the liver by cytochrome P450 3A4-mediated hydrolysis of the 5-fluoromethyl carbothioate grouping. This transformation occurs in 1 metabolic step to produce the inactive 17-(beta)-carboxylic acid metabolite, the only known metabolite detected in man.
Half Life: 10 hours
Dosage Forms of Flixonase: Aerosol, metered Respiratory (inhalation)
Powder Respiratory (inhalation)
Cream Topical
Spray, metered Nasal
Chemical IUPAC Name: [(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
Chemical Formula: C25H31F3O5S
Fluticasone Propionate on Wikipedia: Not Available
Organisms Affected: Humans and other mammals