Fluzon - General Information:

A topical glucocorticoid used in the treatment of eczema. [PubChem]


Fluzon is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema. It relieves itching, redness, dryness, crusting, scaling, inflammation, and discomfort. [Wikipedia]

Fluzon for patients

Patients using topical corticosteroids should receive the following information and instructions:

1. This medication is to be used as directed by the physician. It is for external use only. Avoid contact with the eyes.

2. Patients should be advised not to use this medication for any disorder other than that for which it was prescribed.

3. The treated skin area should not be bandaged or otherwise covered or wrapped as to be occlusive unless directed by the physician.

4. Patients should report any signs of local adverse reactions, especially under occlusive dressing.

5. Parents of pediatric patients should be advised not to use tight-fitting diapers or plastic pants on a child being treated in the diaper area, as these garments may constitute occlusive dressings.

Fluzon Interactions

No information provided.

Fluzon Contraindications

Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.

Additional information about Fluzon

Fluzon Indication: A topical anti-inflammatory product for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
Mechanism Of Action: Fluzon is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema. It relieves itching, redness, dryness, crusting, scaling, inflammation, and discomfort. Fluzon binds to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes. The anti-inflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Specifically glucocorticoids induce lipocortin-1 (annexin-1) synthesis, which then binds to cell membranes preventing the phospholipase A2 from coming into contact with its substrate arachidonic acid. This leads to diminished eicosanoid production. Cyclooxygenase (both COX-1 and COX-2) expression is also suppressed, potentiating the effect. In another words, the two main products in inflammation Prostaglandins and Leukotrienes are inhibited by the action of Glucocorticoids. Glucocorticoids also stimulate the lipocortin-1 escaping to the extracellular space, where it binds to the leukocyte membrane receptors and inhibits various inflammatory events: epithelial adhesion, emigration, chemotaxis, phagocytosis, respiratory burst and the release of various inflammatory mediators (lysosomal enzymes, cytokines, tissue plasminogen activator, chemokines etc.) from neutrophils, macrophages and mastocytes. Additionally the immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Like other glucocorticoid agents Fluocinolone acetonide acts as a physiological antagonist to insulin by decreasing glycogenesis (formation of glycogen). It also promotes the breakdown of lipids (lipolysis), and proteins, leading to the mobilization of extrahepatic amino acids and ketone bodies. This leads to increased circulating glucose concentrations (in the blood). There is also decreased glycogen formation in the liver.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Fluocinonide
Synonyms: Fluocinolide acetate; Fluocinolide; Fluocinolone acetonide acetate; Fluocinonide Emulsified Base; Fluocinonide [USAN:BAN:INN:JAN]; Fluocinonido [INN-Spanish]; Fluocinonidum [INN-Latin]
Drug Category: Anti-Allergic Agents; Anti-inflammatory Agents; Glucocorticoids
Drug Type: Small Molecule; Approved
Other Brand Names containing Fluocinonide: Bestasone; Biscosal; Cortalar; Fluzon; Lidex; Lidex E; Metosyn; Straderm; Synalar acetate; Topsymin; Topsyn; Vanos; Fluonex; Lidex-E; Lonide; Lyderm;
Absorption: The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings.
Toxicity (Overdose): Side effects may include acne-like eruptions, burning, dryness, excessive hair growth, infection of the skin, irritation, itching, lack of skin color, prickly heat, skin inflammation, skin loss or softening, stretch marks
Protein Binding: Not Available
Biotransformation: Primarily hepatic
Half Life: Not Available
Dosage Forms of Fluzon: Gel Topical
Ointment Topical
Cream Topical
Chemical IUPAC Name: Not Available
Chemical Formula: C26H32F2O7
Fluocinonide on Wikipedia: http://en.wikipedia.org/wiki/Fluocinonide
Organisms Affected: Humans and other mammals

Bookmark or Share this page

»Get link codes for this page«
(HTML/BB code)

Search by name browsing our [A-Z] index:


Search by Categories:

See a list of all drugs for sale »

Top5 meds in current month:

*based on number of page views on Flexyx

Visit our friends:

brand and generic ed pills Russian Scientific Center for Restorative Traumatology and Orthopaedics in the name of academician G.A.Ilizarov

Related News

Wed, 21 Sep 2011
Afraid of Flu Shots - Try a Smaller Needle - TIME Healthland
Afraid of the Flu Shot. Try a Smaller Needle. Skip to content. Sanofi Pasteur's Fluzone Intradermal is less than a tenth of an inch long, the first flu vaccine that works by injecting just into the skin. The new needle is about as long as a single drop of fluid.
Source: healthland.time.com »

Fri, 01 Jul 2011
ingentaconnect A theory for microtremor HV spectral ratio - application for a lay
A theory for microtremor H / V spectral ratio: application for a layered medium. Geophysical Journal International, Volume 186, Number 1, July 2011, pp 221-225(5). Buy & download fulltext article. Microtremors are produced by multiple random sources close to the surface of the Earth.
Source: www.ingentaconnect.com »

Mon, 02 May 2011
ingentaconnect Shallow structure of Deception Island, Antarctica, from correlati
Shallow structure of Deception Island, Antarctica, from correlations of ambient seismic noise on a set of dense seismic arrays. Geophysical Journal International, Volume 185, Number 2, May 2011, pp 737-748(12). Buy & download fulltext article.
Source: www.ingentaconnect.com »

Thanks for visiting us!