Fucidin - General Information:

An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed) It acts by inhibiting translocation during protein synthesis.

Pharmacology:

Fusidic acid is a bacteriostatic antibiotic that is often used topically in creams and eyedrops, but may also be given systemically as tablets or injections.

Additional information about Fucidin

Fucidin Indication: For the treatment of bacterial infections.
Mechanism Of Action: Fusidic acid works by interfering with bacterial protein synthesis, specifically by preventing the translocation of the elongation factor G (EF-G) from the ribosome.
Drug Interactions: Amprenavir The protease inhibitor increases the effect and toxicity of fusidic acid
Fosamprenavir The protease inhibitor increases the effect and toxicity of fusidic acid
Nelfinavir The protease inhibitor increases the effect and toxicity of fusidic acid
Ritonavir The protease inhibitor increases the effect and toxicity of fusidic acid
Saquinavir The protease inhibitor increases the effect and toxicity of fusidic acid
Atorvastatin Increased risk of myopathy/rhabdomyolysis
Simvastatin Increased risk of myopathy/rhabdomyolysis
Indinavir Indinavir increases the effect and toxicity of fusidic acid
Food Interactions: Take with food to reduce irritation.
Generic Name: Fusidic Acid
Synonyms: Diethanolamine fusidate; Fucidic acid; Fusidate; Fusidate Sodium; Fucidate Sodium; Fucidate
Drug Category: Antibacterial Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Fusidic Acid: Fucidin Cream 2%; Fucithalmic; Fusidine; Ramycin; Fucidin; Fucidin acid; Fucidine;
Absorption: Sodium fusidic acid tablets have a 91% oral bioavailability. Absorption of the film-coated tablets is complete when compared to a solution, however oral absorption is variable. Oral fusidic acid hemihydrate (suspension) achieved a 22.5% bioavailability in pediatric patients following a 20 milligram/kilogram dose.
Toxicity (Overdose): Not Available
Protein Binding: 97 to 99%
Biotransformation: Metabolites include dicarboxylic ester/acid, 3-keto fusidic acid, hydroxy fusidic acid, glucuronide fusidic acid and a glycol metabolite.
Half Life: Approximately 5 to 6 hours in adults.
Dosage Forms of Fucidin: Not Available
Chemical IUPAC Name: (2Z)-2-[(3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoic acid
Chemical Formula: C31H48O6
Fusidic Acid on Wikipedia: http://en.wikipedia.org/wiki/Fusidic_acid
Organisms Affected: Enteric bacteria and other eubacteria

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