Gastron - General Information:

Gastron is a synthetic antispasmodic. Antispasmodics are used to relieve cramps or spasms of the stomach, intestines, and bladder. Gastron is used to treat intestine or stomach ulcers (peptic ulcer disease), intestine problems (irritable bowel syndrome), pancreatitis, gastritis, biliary dyskinesia, pylorosplasm, or urinary problems (reflex neurogenic bladder in children).


Gastron is a synthetic quarternary ammonium antimuscarinic used to relieve cramps or spasms of the stomach, intestines, and bladder. It can be used together with antacids or other medicines, such as H2-receptor antagonists, in the treatment of peptic ulcer. Gastron inhibits muscarinic actions at postganglionic parasympathetic neuroeffector sites.

Gastron for patients

Gastron Interactions

This drug may interact with the following: antacids, diarrhea medicine containing kaolin or attapulgite, ketoconazole (using these medicines with an anticholinergic may lessen the effects of the anticholinergic), central nervous system (CNS) depressants (taking scopolamine with CNS depressants may increase the effects of either medicine), other anticholinergics (medicine for abdominal or stomach spasms or cramps), tricyclic antidepressants (taking anticholinergics with tricyclic antidepressants or other anticholinergics may cause an increase in the effects of the anticholinergic), and potassium chloride (using this medicine with an anticholinergic may make gastrointestinal problems caused by potassium worse).

Gastron Contraindications

Contraindicated in the following: hypersensitivity to anticholinergics, narrow-angle glaucoma, GI obstruction, myasthenia gravis, paralytic ileus, GI atony, and toxic megacolon.

Additional information about Gastron

Gastron Indication: For the treatment of peptic ulcer disease, irritable bowel syndrome, pancreatitis, gastritis, biliary dyskinesia, pylorosplasm, and reflex neurogenic bladder in children.
Mechanism Of Action: Gastron inhibits the muscarinic actions of acetylcholine on structures innervated by postganglionic cholinergic nerves as well as on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These postganglionic receptor sites are present in the autonomic effector cells of the smooth muscle, cardiac muscle, sinoatrial and atrioventricular nodes, and exocrine glands. Depending on the dose, anticholinergics may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a slight relaxant action on the bile ducts and gallbladder.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Methantheline
Synonyms: Methantheline Bromide; Methanthelinium; Methanthelinium Bromide; Methanthelinum; Methanthine Bromide; MTB 51; Banthine Bromide
Drug Category: Anticholinergic Agents; Antispasmodics
Drug Type: Small Molecule; Approved
Other Brand Names containing Methantheline: Asabaine; Avagal; Banthin; Banthine; Dixamone Bromide; Doladene; Frenogastrico; Gastrin I; Gastrin-1 Human; Gastron; Gastrosedan; Mantheline; Metantyl; Metaxan; Methanide; Methelina; Resobantin; Ulcine; Ulcudexter; Vagamin; Vagantin; Xanteline;
Absorption: Rapidly absorbed.
Toxicity (Overdose): Symptoms of overdose: blurred vision (continuing) or changes in near vision, clumsiness or unsteadiness, confusion, convulsions, difficulty in breathing, muscle weakness (severe), or tiredness (severe), dizziness, drowsiness (severe), dryness of mouth, nose, or throat (severe), fast heartbeat, fever, hallucinations, slurred speech, unusual excitement, nervousness, restlessness, or irritability, unusual warmth, dryness, and flushing of skin.
Protein Binding: Not Available
Biotransformation: Hepatic, by enzymatic hydrolysis.
Half Life: Not Available
Dosage Forms of Gastron: Tablet Oral
Chemical IUPAC Name: diethyl-methyl-[2-(9H-xanthene-9-carbonyloxy)ethyl]azanium
Chemical Formula: C21H26NO3+
Methantheline on Wikipedia: Not Available
Organisms Affected: Humans and other mammals

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