Flexyx

Flexyx drugs: Gemfibril

Gemfibril - General Information:

A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol. These decreases occur primarily in the VLDL fraction and less frequently in the LDL fraction. Gemfibril increases HDL subfractions HDL2 and HDL3 as well as apolipoproteins A-I and A-II. Its mechanism of action has not been definitely established. [PubChem]


Related offers from our Drug Store:

Lopid (Gemfibrozil) - for $77.29 Lopid (also known as a fibrate medication) is used along with a proper diet to help lower fats (triglycerides) and cholesterol in the blood. This drug is usually prescribed after non-drug treatment options have not been fully successful at lowering cholesterol (e.g., diet change, increase in exercise, weight loss if overweight). This drug is thought to work by decreasing the amount of fat produced by the liver. Reducing cholesterol and triglycerides lowers the risk of heart disease and helps prevent strokes and heart attacks. This drug also helps to prevent pancreas disease (pancreatitis) in patients with very high blood levels of triglycerides.

* >> all this drugs based on Gemfibrozil (usually they can be used instead of Gemfibril)

Related offer from MedStore:

Generic Lopid (Gemfibrozil) - 300mg 30 pills for $42.78 Lopid (Gemfibrozil) is a lipid-regulating agent used to lower cholesterol and triglyceride levels in your blood.

Pharmacology:

Gemfibril, a fibric acid antilipemic agent similar to clofibrate, is used to treat hyperlipoproteinemia and as a second-line therapy for type IIb hypercholesterolemia. It acts to reduce triglyceride levels, reduce VLDL levels, reduce LDL levels (moderately), and increase HDL levels (moderately).

Gemfibril for patients

Gemfibrozil is used to lower high triglyceride and cholesterol levels. Notify your physician if you are pregnant or nursing. Gemfibrozil should be taken 30 minutes before the morning and evening meals. This medication may cause dizziness or blurred vision; use caution while driving or operating hazardous machinery. Gemfibrozil may cause an increase in blood sugar. If you have diabetes mellitus, carefully monitor blood sugar levels. Notify your physician if you develop severe stomach pain, muscle pain or weakness, or unexplained fever.

Gemfibril Interactions

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Clinical Laboratory
	increased creatine	positive antinuclear
	phosphokinase	antibody
	increased bilirubin
	increased liver
	transaminases (AST
	(SGOT), ALT (SGPT)
	increased alkaline
	phophatase
Hematopoietic	anemia	thrombocytopenia
	leukopenia
	bone marrow hypoplasia
	eosinophilia
Immunologic	angioedema	anaphylaxis
	laryngeal edema	Lupus-like syndrome
	urticaria	vasculitis
Integumentary	exfoliative dermatitis	alopecia
	rash
	dermatitis
	pruritus

Gemfibril Contraindications

1. Combination therapy of LOPID with cerivastatin due to the increased risk of myopathy and rhabdomyolysis.

2. Hepatic or severe renal dysfunction, including primary biliary cirrhosis.

3. Preexisting gallbladder disease.

4. Hypersensitivity to gemfibrozil.

Additional information about Gemfibril

Gemfibril Indication: For treatment of adult patients with very high elevations of serum triglyceride levels (types IV and V hyperlipidemia) who are at risk of developing pancreatitis (inflammation of the pancreas) and who do not respond adequately to a strict diet.
Mechanism Of Action: Gemfibril increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride lipolysis. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL. This is accompanied by a slight increase in secretion of lipids into the bile and ultimately the intestine. Gemfibril also inhibits the synthesis and increases the clearance of apolipoprotein B, a carrier molecule for VLDL.
Drug Interactions: Anisindione Gemfibril increases the anticoagulant effect
Dicumarol Gemfibril increases the anticoagulant effect
Acenocoumarol Gemfibril increases the anticoagulant effect
Warfarin Gemfibril increases the anticoagulant effect
Atorvastatin Increased risk of myopathy/rhabdomyolysis
Cerivastatin Increased risk of myopathy/rhabdomyolysis
Fluvastatin Increased risk of myopathy/rhabdomyolysis
Lovastatin Increased risk of myopathy/rhabdomyolysis
Pioglitazone Increases the effect and toxicity of rosiglitazone/pioglitazone
Rosiglitazone Increases the effect and toxicity of rosiglitazone/pioglitazone
Pravastatin Increased risk of myopathy/rhabdomyolysis
Simvastatin Increased risk of myopathy/rhabdomyolysis
Repaglinide Increases the effect and toxicity of repaglinide
Rosuvastatin Rosuvastatin possibly increases the effect of the fibrate
Ursodeoxycholic acid The fibric acid derivative decreases the effect of ursodiol
Food Interactions: Take 30 minutes before meals.
Generic Name: Gemfibrozil
Synonyms: Not Available
Where to order Gemfibrozil (and Gemfibril analogs) online:
Drug Category: Antilipemic Agents; Fribic Acid Derivatives
Drug Type: Small Molecule; Approved
Other Brand Names containing Gemfibrozil: Apo-Gemfibrozil; Bolutol; Cholespid; Decrelip; Fibratol; Fibrocit; Gemfibril; Gemfibromax; Gemlipid; Gen-Fibro; Genlip; Gevilon; Hipolixan; Jezil; Lipozid; Lipur; Lopid; Novo-Gemfibrozil; Nu-Gemfibrozil;
Absorption: Well absorbed from gastrointestinal tract (within 1-2 hours).
Toxicity (Overdose): Oral, mouse: LD₅₀ = 3162 mg/kg. Symptoms of overdose include abdominal cramps, diarrhea, joint and muscle pain, nausea, and vomiting.
Protein Binding: 95%
Biotransformation: Hepatic. Gemfibrozil mainly undergoes oxidation of a ring methyl group to successively form a hydroxymethyl and a carboxyl metabolite.
Half Life: 1.5 hours
Dosage Forms of Gemfibril: Tablet Oral
Capsule Oral
Chemical IUPAC Name: 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid
Chemical Formula: C15H22O3
Gemfibrozil on Wikipedia: http://en.wikipedia.org/wiki/Gemfibrozil
Organisms Affected: Humans and other mammals