Gen-Fibro - General Information:

A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol. These decreases occur primarily in the VLDL fraction and less frequently in the LDL fraction. Gen-Fibro increases HDL subfractions HDL2 and HDL3 as well as apolipoproteins A-I and A-II. Its mechanism of action has not been definitely established. [PubChem]

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Gen-Fibro - Pharmacology:

Gen-Fibro, a fibric acid antilipemic agent similar to clofibrate, is used to treat hyperlipoproteinemia and as a second-line therapy for type IIb hypercholesterolemia. It acts to reduce triglyceride levels, reduce VLDL levels, reduce LDL levels (moderately), and increase HDL levels (moderately).

Gen-Fibro for patients

Gemfibrozil is used to lower high triglyceride and cholesterol levels. Notify your physician if you are pregnant or nursing. Gemfibrozil should be taken 30 minutes before the morning and evening meals. This medication may cause dizziness or blurred vision; use caution while driving or operating hazardous machinery. Gemfibrozil may cause an increase in blood sugar. If you have diabetes mellitus, carefully monitor blood sugar levels. Notify your physician if you develop severe stomach pain, muscle pain or weakness, or unexplained fever.

Gen-Fibro Interactions

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 Clinical Laboratory
 

increased creatine

positive antinuclear

 

phosphokinase

antibody

 

increased bilirubin

 
 

increased liver

 
 

transaminases (AST

 
 

(SGOT), ALT (SGPT)

 
 

increased alkaline

 
 

phophatase

 
 Hematopoietic

anemia

thrombocytopenia

 

leukopenia

 
 

bone marrow hypoplasia

 
 

eosinophilia

 
 Immunologic

angioedema

anaphylaxis

 

laryngeal edema

Lupus-like syndrome

 

urticaria

vasculitis

 Integumentary

exfoliative dermatitis

alopecia

 

rash

 
 

dermatitis

 
 

pruritus

 


Gen-Fibro Contraindications

1. Combination therapy of LOPID with cerivastatin due to the increased risk of myopathy and rhabdomyolysis.

2. Hepatic or severe renal dysfunction, including primary biliary cirrhosis.

3. Preexisting gallbladder disease.

4. Hypersensitivity to gemfibrozil.

Gen-Fibro more info

Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..