Gen-Fibro - General Information:

A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol. These decreases occur primarily in the VLDL fraction and less frequently in the LDL fraction. Gen-Fibro increases HDL subfractions HDL2 and HDL3 as well as apolipoproteins A-I and A-II. Its mechanism of action has not been definitely established. [PubChem]

    Pharmacology:

    Gen-Fibro, a fibric acid antilipemic agent similar to clofibrate, is used to treat hyperlipoproteinemia and as a second-line therapy for type IIb hypercholesterolemia. It acts to reduce triglyceride levels, reduce VLDL levels, reduce LDL levels (moderately), and increase HDL levels (moderately).

    Gen-Fibro for patients

    Gemfibrozil is used to lower high triglyceride and cholesterol levels. Notify your physician if you are pregnant or nursing. Gemfibrozil should be taken 30 minutes before the morning and evening meals. This medication may cause dizziness or blurred vision; use caution while driving or operating hazardous machinery. Gemfibrozil may cause an increase in blood sugar. If you have diabetes mellitus, carefully monitor blood sugar levels. Notify your physician if you develop severe stomach pain, muscle pain or weakness, or unexplained fever.

    Gen-Fibro Interactions

    )

     
     Clinical Laboratory
     

    increased creatine

    positive antinuclear

     

    phosphokinase

    antibody

     

    increased bilirubin

     
     

    increased liver

     
     

    transaminases (AST

     
     

    (SGOT), ALT (SGPT)

     
     

    increased alkaline

     
     

    phophatase

     
     Hematopoietic

    anemia

    thrombocytopenia

     

    leukopenia

     
     

    bone marrow hypoplasia

     
     

    eosinophilia

     
     Immunologic

    angioedema

    anaphylaxis

     

    laryngeal edema

    Lupus-like syndrome

     

    urticaria

    vasculitis

     Integumentary

    exfoliative dermatitis

    alopecia

     

    rash

     
     

    dermatitis

     
     

    pruritus

     


    Gen-Fibro Contraindications

    1. Combination therapy of LOPID with cerivastatin due to the increased risk of myopathy and rhabdomyolysis.

    2. Hepatic or severe renal dysfunction, including primary biliary cirrhosis.

    3. Preexisting gallbladder disease.

    4. Hypersensitivity to gemfibrozil.

    Gen-Fibro more info

    Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..