Glurenorm - General Information:

Glurenorm is an anti-diabetic drug in the sulfonylurea class. It is used in the treatment of diabetes mellitus type 2. It is an ATP-dependent K+ (KATP) channel blocker. This block causes a depolarization which leads to activation of voltage-dependent Ca channels and Ca2+ influx, and eventually increases insulin release.


Glurenorm is an anti-diabetic drug in the sulfonylurea class. In patients with diabetes mellitus, there is a deficiency or absence of a hormone manufactured by the pancreas called insulin. Insulin is the main hormone responsible for the control of sugar in the blood. Glurenorm is an antidiabetic medication which is used in those patients with adult maturity onset or non-insulin dependent diabetes (NIDDM). It works by lowering blood sugar levels by stimulating the production and release of insulin from the pancreas. It also promotes the movement of sugar from the blood into the cells in the body which need it.

Additional information about Glurenorm

Glurenorm Indication: Used in the treatment of diabetes mellitus type 2.
Mechanism Of Action: The mechanism of action of gliquidone in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells, and increasing sensitivity of peripheral tissues to insulin. Glurenorm likely binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Membrane depolarization stimulates calcium ion influx through voltage-sensitive calcium channels. This increase in intracellular calcium ion concentration induces the secretion of insulin.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Gliquidone
Synonyms: Not Available
Drug Category: Sulfonylureas; Hypoglycemic Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Gliquidone: Glurenorm;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: The mean terminal half-life was approximately 8 hours (range 5.7-9.4 hours)
Dosage Forms of Glurenorm: Not Available
Chemical IUPAC Name: 1-cyclohexyl-3-[4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxoisoquinolin-2-yl)ethyl]phenyl]sulfonylurea
Chemical Formula: C27H33N3O6S
Gliquidone on Wikipedia:
Organisms Affected: Humans and other mammals

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