Glycerylguaiacolate carbamate - General Information:A centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1206)
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Pharmacology:Glycerylguaiacolate carbamate is a central muscle relaxant for skeletal muscles, used to treat spasms. It is structurally related to guaifenesin. Glycerylguaiacolate carbamate's exact mechanism of causing skeletal muscle relaxation is unknown. It is thought to work centrally, perhaps by general depressant effects. It has no direct relaxant effects on striated muscle, nerve fibers, or the motor endplate. It will not directly relax contracted skeletal muscles. The drug has a secondary sedative effect.
Glycerylguaiacolate carbamate for patients
Glycerylguaiacolate carbamate Interactions
No information available.
Glycerylguaiacolate carbamate Contraindications
Methocarbamol Tablets are contraindicated in patients hypersensitive to any of the ingredients.
Additional information about Glycerylguaiacolate carbamateGlycerylguaiacolate carbamate Indication: For use as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions.
Mechanism Of Action: The mechanism of action of methocarbamol in humans has not been established, but may be due to central nervous system depression. It has no direct action on the contractile mechanism of striated muscle, the motor end plate or the nerve fiber.
Drug Interactions: Not Available
Food Interactions: Avoid alcohol.
Generic Name: Methocarbamol
Synonyms: Not Available
Drug Category: Muscle Relaxants, Central
Drug Type: Small Molecule; Approved
Other Brand Names containing Methocarbamol: AHR 85; Avetil; Delaxin; Etroflex; Forbaxin; Glycerylguaiacolate carbamate; Glycerylguajacol-Carbamat; Guaiacol glyceryl ether carbamate; Guaiphenesin carbamate; Guaiphenesine carbamate; Lumirelax; Methocal; Metocarbamol; Metocarbamolo; Metofenia; Metofenina; Miolaxene; Miorilas; Miowas; Myolaxene; Neuraxin; Parabaxin; Perilax; Reflexyn; Relestrid; Robamol; Robaxan; Robaxin; Robaxine; Robaxon; Robinax; Romethocarb; Surquetil; Traumacut; Tresortil;
Absorption: Rapid. Onset of action is about 30 minutes after oral administration.
Toxicity (Overdose): Symptoms of overdose include blurred vision, coma, drowsiness, low blood pressure, nausea, and seizures.
Protein Binding: Not Available
Half Life: 1.14-1.24 hours
Dosage Forms of Glycerylguaiacolate carbamate: Tablet Oral
Chemical IUPAC Name: [2-hydroxy-3-(2-methoxyphenoxy)propyl] carbamate
Chemical Formula: C11H15NO5
Methocarbamol on Wikipedia: http://en.wikipedia.org/wiki/Methocarbamol
Organisms Affected: Humans and other mammals
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