Flexyx

Flexyx drugs: Haldrone

Haldrone - General Information:

A glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than hydrocortisone with supplementary fludrocortisone. (From Martindale, The Extra Pharmacopoeia, 30th ed, p737)

Pharmacology:

Haldrone is a glucocorticoid with the general properties of corticosteroids.

Additional information about Haldrone

Haldrone Indication: For the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than hydrocortisone with supplementary fludrocortisone.
Mechanism Of Action: Glucocorticoids such as paramethasone can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The antiinflammatory actions of glucocorticoids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Haldrone reduces inflammatory reaction by limiting the capillary dilatation and permeability of the vascular structures. These compounds restrict the accumulation of polymorphonuclear leukocytes and macrophages and reduce the release of vasoactive kinins. Recent research suggests that corticosteroids may inhibit the release of arachidonic acid from phospholipids, thereby reducing the formation of prostaglandins. Prednisolone is a glucocorticoid receptor agonist. On binding, the corticoreceptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing an increase or decrease in expression of specific target genes, including suppression of IL2 (interleukin 2) expression.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Paramethasone
Synonyms: Not Available
Where to order Paramethasone (and Haldrone analogs) online:
Drug Category: Anti-inflammatory Agents; Glucocorticoids
Drug Type: Small Molecule; Approved
Other Brand Names containing Paramethasone: Haldrone;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: 80%
Biotransformation: Hepatic.
Half Life: Not Available
Dosage Forms of Haldrone: Tablet Oral
Chemical IUPAC Name: (6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
Chemical Formula: C22H29FO5
Paramethasone on Wikipedia: http://en.wikipedia.org/wiki/Paramethasone
Organisms Affected: Humans and other mammals