Hydromox R - General Information:

An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Hydromox R inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use. [PubChem]

Pharmacology:

Hydromox R is an adrenergic blocking agent used to treat mild to moderate hypertension via the disruption of norepinephrine vesicular storage. The antihypertensive actions of Hydromox R are a result of its ability to deplete catecholamines from peripheral sympathetic nerve endings. These substances are normally involved in controlling heart rate, force of cardiac contraction and peripheral resistance.

Additional information about Hydromox R

Hydromox R Indication: Foe the treatment of hypertension
Mechanism Of Action: Hydromox R's mechanism of action is through inhibition of the ATP/Mg2+ pump responsible for the sequestering of neurotransmitters into storage vesicles located in the presynaptic neuron. The neurotransmitters that are not sequestered in the storage vesicle are readily metabolized by monoamine oxidase (MAO) causing a reduction in catecholamines.
Drug Interactions: Dobutamine Increased arterial pressure
Dopamine Increased arterial pressure
Ephedrine Increased arterial pressure
Ephedra Increased arterial pressure
Epinephrine Increased arterial pressure
Norepinephrine Increased arterial pressure
Terbutaline Increased arterial pressure
Salbutamol Increased arterial pressure
Pseudoephedrine Increased arterial pressure
Procaterol Increased arterial pressure
Pirbuterol Increased arterial pressure
Phenylpropanolamine Increased arterial pressure
Phenylephrine Increased arterial pressure
Orciprenaline Increased arterial pressure
Methoxamine Increased arterial pressure
Metaraminol Increased arterial pressure
Mephentermine Increased arterial pressure
Isoproterenol Increased arterial pressure
Fenoterol Increased arterial pressure
Food Interactions: Not Available
Generic Name: Reserpine
Synonyms: Not Available
Drug Category: Antipsychotics; Antihypertensive Agents; Peripheral Adrenergic Inhibitors
Drug Type: Small Molecule; Approved
Other Brand Names containing Reserpine: Cam-Ap-Es; Demi-Regroton; Diupres-250; Diupres-500; Diutensen-R; Dralserp; Hiserpia; Hydrap-ES; Hydromox R; Hydroserpine Plus (R-H-H); Metatensin;
Absorption: Not Available
Toxicity (Overdose): Possible human carcinogen. May cause reproductive harm. ORL-RAT LD50 420 mg/kg; IPR-RAT LD50 44 mg/kg; IVN-RAT LD50 15 mg/kg; ORL-MUS LD50 200 mg/kg; SCU-MUS LD50 52 mg/kg; IPR-RBT LD50 7 mg/kg
Protein Binding: 62%
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Hydromox R: Tablet Oral
Chemical IUPAC Name: Not Available
Chemical Formula: C33H40N2O9
Reserpine on Wikipedia: http://en.wikipedia.org/wiki/Reserpine
Organisms Affected: Humans and other mammals

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