Imodium - General Information:One of the long-acting synthetic antidiarrheals; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally. [PubChem]
Other Brand Names containing Loperamide
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Imodium - Pharmacology:
In vitro and animal studies show that Imodium acts by slowing intestinal motility and by affecting water and electrolyte movement through the bowel. Imodium inhibits peristaltic activity by a direct effect on the circular and longitudinal muscles of the intestinal wall. It is a non-selective calcium channel blocker and binds to opioid mu-receptors. Evidence also suggests that at higher concentrations it binds to NMDA receptors and to calmodulin.
Imodium for patients
Patients should be advised to check with their physician if their diarrhea does not improve after a couple of days or if they note blood in their stools or develop a fever.
There was no evidence in clinical trials of drug interactions with concurrent medications.
Loperamide hydrochloride is contraindicated in patients with known hypersensitivity to the drug and in those in whom constipation must be avoided.
Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..