Lesterol - General Information:

A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).

Pharmacology:

Lesterol is a powerful antioxidant drug normally used to prevent vascular disease caused by the free radicals in the body.

Additional information about Lesterol

Lesterol Indication: Used to lower LDL and HDL cholesterol.
Mechanism Of Action: Lesterol lowers serum cholesterol by increasing the fractional rate of low-density lipoprotein (LDL) catabolism in the final metabolic pathway for cholesterol elimination from the body. Additionally, probucol may inhibit early stages of cholesterol biosynthesis and slightly inhibit dietary cholesterol absorption. Recent information suggests that probucol may inhibit the oxidation and tissue deposition of LDL cholesterol, thereby inhibiting atherogenesis.
Drug Interactions: Cyclosporine Lesterol decreases the effect of cyclosporine
Food Interactions: Not Available
Generic Name: Probucol
Synonyms: 4,4'- (Isopropylidenedithio)bis(2, 6-di-tert-butylphenol); 4,4'-(Isopropylidenedithio)bis(2, 6-di-tert-butylphenol); 4,4'-(Isopropylidenedithio)bis(2,6-di-tert-butylphenol); 4,4'-(Isopropylidenedithio)bis[2, 6-di-tert-butylphenol]; Acetone bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole; Acetone, bis (3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole; Acetone, bis(3,5-di-tert-butyl-4-hydroxyphenyl) mercaptole; Probucolum [inn-latin]
Drug Category: Anticholesteremic Agents; Antioxidants
Drug Type: Small Molecule; Approved
Other Brand Names containing Probucol: Biphenabid; Bisbid; Bisphenabid; Lesterol; Lorelco; Lursell; Lurselle; Panavir; Sinlestal;
Absorption: Absorption from the gastrointestinal tract is limited and variable (about 7%).
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Ranges from 12 hours to more than 500 hours, the longest half-life probably being in adipose tissue.
Dosage Forms of Lesterol: Tablet Oral
Tablet Oral
Chemical IUPAC Name: 2,6-ditert-butyl-4-[2-(3,5-ditert-butyl-4-hydroxyphenyl)sulfanylpropan-2-ylsulfanyl]phenol
Chemical Formula: C31H48O2S2
Probucol on Wikipedia: http://en.wikipedia.org/wiki/Probucol
Organisms Affected: Humans and other mammals

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