Mezlin - General Information:

Semisynthetic ampicillin-derived acylureido penicillin. It has been proposed for infections with certain anaerobes and may be useful in inner ear, bile, and CNS infections. [PubChem]

Pharmacology:

Mezlin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Mezlin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of mezlocillin results from the inhibition of cell wall synthesis and is mediated through mezlocillin binding to penicillin binding proteins (PBPs). Mezlin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. Mezlin can be used to treat susceptible strains of H. influenzae, Klebsiella species, Pseudomonas species, Proteus mirabilis, E. coli, Enterobacter species, Streptococcus faecelis, Peptococcus species, Peptostreptococcus species, Bacteriodes species (including B. fragilis), Morganella morganii, Serratia species, N. gonorrhoeae, P. vulgaris, and Providencia rettgeri. This drug is discontinued in the U.S.

Additional information about Mezlin

Mezlin Indication: Used to treat serious gram–negative infections of the lungs, urinary tract, and skin.
Mechanism Of Action: By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, mezlocillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that mezlocillin interferes with an autolysin inhibitor.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Mezlocillin
Synonyms: Not Available
Drug Category: Anti-Bacterial Agents; Penicillins
Drug Type: Small Molecule; Approved
Other Brand Names containing Mezlocillin: Mezlin;
Absorption: Not Available
Toxicity (Overdose): Symptoms of overdose include rash, fever, chills, and peeling skin.
Protein Binding: 16-59%
Biotransformation: Unlike many other penicillins, mezlocillin is either extensively metabolized or is subject to biliary excretion, as only about 50% of the dose was accounted for in normal urine.
Half Life: 1.3 to 4.4 hours
Dosage Forms of Mezlin: Not Available
Chemical IUPAC Name: (2S,5R,6R)-3,3-dimethyl-6-[[(2R)-2-[(3-methylsulfonyl-2-oxoimidazolidine-1-carbonyl)amino]-2-phenylacetyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Chemical Formula: C21H25N5O8S2
Mezlocillin on Wikipedia: http://en.wikipedia.org/wiki/Mezlocillin
Organisms Affected: Enteric bacteria and other eubacteria

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