Flexyx

Flexyx drugs: Micoserina

Micoserina - General Information:

Antibiotic substance produced by Streptomyces garyphalus. [PubChem]

Pharmacology:

Micoserina, a broad-spectrum antibiotic, may be bactericidal or bacteriostatic, depending on its concentration at the site of infection and the susceptibility of the organism. Micoserina works by blocking the formation of these peptidoglycans. By doing this the walls of the bacteria become weak and it results in the death of the bacteria

Micoserina for patients

Take this by mouth as directed usually every 12 hours for the first two weeks. This medication works best when the amount of medicine in your body is kept at a constant level. Do this by taking the medication at evenly spaced intervals throughout the day and night. Continue using this for the full time prescribed. It may be necessary to continue therapy for tuberculosis for several months to one year or more. Stopping the medication too early may result in ineffective treatment.

Micoserina Interactions

May interact with wthionamide (Trecator-SC) and isoniazid (Nydrazid).

Micoserina Contraindications

Additional information about Micoserina

Micoserina Indication: Used in combination with up to 5 other drugs as a treatment for Mycobacterium avium complex (MAC) and is also used to treat tuberculosis (TB).
Mechanism Of Action: Micoserina is an analog of the amino acid D-alanine. It interferes with an early step in bacterial cell wall synthesis in the cytoplasm by competitive inhibition of two enzymes, L-alanine racemase, which forms D-alanine from L-alanine, and D-alanylalanine synthetase, which incorporates D-alanine into the pentapeptide necessary for peptidoglycan formation and bacterial cell wall synthesis.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Cycloserine
Synonyms: alpha-Cycloserine; Cicloserina; D-CS; D-Cycloserine; D-Cycloserine synth. BP 88; D-Cycloserine, synthetic; D-Oxamicina; D-Oxamycin; DL-Cycloserine; L-Cycloserine
Where to order Cycloserine (and Micoserina analogs) online:
Drug Category: Antibiotics
Drug Type: Small Molecule; Approved
Other Brand Names containing Cycloserine: Closerin; Closina; Cyclomycin; Cyclorin; Cycloserin; Farmiserina; Farmiserine; Micoserina; Miroserina; Miroseryn; Novoserin; Orientomycin; Oxamicina; Oxamycin; Oxymycin; Seromycin; Tebemicina; Tisomycin; Wasserina;
Absorption: Rapidly and almost completely absorbed (70 to 90%) from the gastrointestinal tract following oral administration.
Toxicity (Overdose): Oral LD₅₀ in mouse is 5290 mg/kg, and in rat is over 5000 mg/kg. Symptoms of a cycloserine overdose include drowsiness, confusion, headache, dizziness, irritability, numbness and tingling, difficulty speaking, paralysis, abnormal behavior, seizures, and unconsciousness.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Half-life in patients with normal renal function is 10 hours, and is prolonged in patients with impaired renal function.
Dosage Forms of Micoserina: Capsule Oral
Chemical IUPAC Name: 4-amino-1,2-oxazolidin-3-one
Chemical Formula: C3H6N2O2
Cycloserine on Wikipedia: http://en.wikipedia.org/wiki/Cycloserine
Organisms Affected: Enteric bacteria and other eubacteria