Moditen - General Information:Moditen is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. Moditen exists as small alkaline deliquescent crystals with a saline taste.
Moditen was introduced to medicine as a solvent for uric acid. When taken into the body the drug is partly oxidized and partly eliminated unchanged. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful.
Moditen was first introduced as an anthelmintic in 1953. A large number of piperazine compounds have anthelmintic action. Their mode of action is generally by paralysing parasites, which allows the host body to easily remove or expel the invading organism.
Other Brand Names containing Piperazine
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Moditen - Pharmacology:
Moditen is a GABA receptor agonist. Piperzine binds directly and selectively to muscle membrane GABA receptors, presumably causing hyperpolarization of nerve endings, resulting in flaccid paralysis of the worm. While the worm is paralyzed, it is dislodged from the intestinal lumen and expelled live from the body by normal intestinal peristalsis.
Moditen for patients
Phenothiazines - Taking piperazine and a phenothiazine together may increase the risk of convulsions (seizures).
Pyrantel (e.g., Antiminth) - Taking piperazine and pyrantel together may decrease the effects of piperazine.
Patients with hypersensitivity to piperazine salts or a history of renal function impairment should avoid this medication
Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..