Nalone - General Information:

A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors. [PubChem]


Nalone is an opiate antagonist and prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Also, it can reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine. Nalone is an essentially pure narcotic antagonist, i.e., it does not possess the "agonistic" or morphine-like properties characteristic of other narcotic antagonists; naloxone does not produce respiratory depression, psychotomimetic effects or pupillary constriction. In the absence of narcotics or agonistic effects of other narcotic antagonists, it exhibits essentially no pharmacologic activity.

Nalone for patients

Nalone Interactions

No information provided.

Nalone Contraindications

Naloxone Hydrochloride Injection is contraindicated in patients known to be hypersensitive to it.

Additional information about Nalone

Nalone Indication: For the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids including natural and synthetic narcotics, propoxyphene, methadone and the narcotic-antagonist analgesics: nalbuphine, pentazocine and butorphanol.
Mechanism Of Action: While the mechanism of action of naloxone is not fully understood, the preponderance of evidence suggests that naloxone antagonizes the opioid effects by competing for the same receptor sites, especially the opioid mu receptor. Recently, naloxone has been shown to bind all three opioid receptors (mu, kappa and gamma) but the strongest binding is to the mu receptor.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Naloxone
Synonyms: L-Naloxone; N-Allylnoroxymorphone; EN 1530 Base; Nalossone [Dcit]; Naloxona [Inn-Spanish]; Naloxone HCl; Naloxonum [Inn-Latin]
Drug Category: Antinarcotic Agents; Depressants; Opiate Antagonists
Drug Type: Small Molecule; Approved
Other Brand Names containing Naloxone: Nalone; Narcan; Narcanti; Narcon;
Absorption: Well absorbed following intramuscular injection.
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Hepatic.
Half Life: 30-81 minutes
Dosage Forms of Nalone: Liquid Intravenous
Chemical IUPAC Name: Not Available
Chemical Formula: C19H21NO4
Naloxone on Wikipedia:
Organisms Affected: Humans and other mammals

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