Neuleptil - General Information:

Neuleptil is a phenothiazine of the piperidine group. It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. It is a sedative phenothiazine with weak antipsychotic properties. It also has adrenolytic, anticholinergic, metabolic and endocrine effects and an action on the extrapyramidal system. It is used as an adjunctive medication in some psychotic patients, for the control of residual prevailing hostility, impulsiveness and aggressiveness. Pericyazine, like other phenothiazines, is presumed to act principally in the subcortical areas, by producing what has been described as a central adrenergic blockade.

Pharmacology:

Pericyazine is a phenothiazine of the piperidine group. It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. It is a sedative phenothiazine with weak antipsychotic properties. It also has adrenolytic, anticholinergic, metabolic and endocrine effects, and an action on the extrapyramidal system.

Additional information about Neuleptil

Neuleptil Indication: For use as adjunctive medication in some psychotic patients, for the control of residual prevailing hostility, impulsiveness and aggressiveness.
Mechanism Of Action: Pericyazine, like other phenothiazines, is presumed to act principally in the subcortical areas, by producing what has been described as a central adrenergic blockade.
Drug Interactions: Amphetamine Decreased anorexic effect, may increase pyschotic symptoms
Benzphetamine Decreased anorexic effect, may increase pyschotic symptoms
Dextroamphetamine Decreased anorexic effect, may increase pyschotic symptoms
Dexfenfluramine Decreased anorexic effect, may increase pyschotic symptoms
Fenfluramine Decreased anorexic effect, may increase pyschotic symptoms
Diethylpropion Decreased anorexic effect, may increase pyschotic symptoms
Guanethidine The agent decreases the effect of guanethidine
Mazindol Decreased anorexic effect, may increase pyschotic symptoms
Methamphetamine Decreased anorexic effect, may increase pyschotic symptoms
Metrizamide Increased risk of convulsions
Phendimetrazine Decreased anorexic effect, may increase pyschotic symptoms
Phenmetrazine Decreased anorexic effect, may increase pyschotic symptoms
Phentermine Decreased anorexic effect, may increase pyschotic symptoms
Phenylpropanolamine Decreased anorexic effect, may increase pyschotic symptoms
Rivastigmine Possible antagonism of action
Galantamine Possible antagonism of action
Donepezil Possible antagonism of action
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Food Interactions: Not Available
Generic Name: Propericiazine
Synonyms: Pericyazine
Drug Category: Phenothiazines; Antipsychotic Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Propericiazine: Neuleptil;
Absorption: Not Available
Toxicity (Overdose): In milder cases of phenothiazine overdosage the patient may be agitated, delirious and confused. Frequently he is lethargic or in a comatose state. Twitching, dystonic movements or convulsions may be present and hypotension, cardiovascular collapse, arrhythmias and hypothermia might be observed.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Neuleptil: Not Available
Chemical IUPAC Name: 10-[3-(4-hydroxypiperidin-1-yl)propyl]phenothiazine-2-carbonitrile
Chemical Formula: C21H23N3OS
Propericiazine on Wikipedia: Not Available
Organisms Affected: Humans and other mammals

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