Nicergolina [Dcit] - General Information:

An ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It has been suggested to ameliorate cognitive deficits in cerebrovascular disease. [PubChem]

Pharmacology:

Nicergolina [Dcit] is a potent vasodilator (improves brain blood flow). On the cerebral level it prompts a lowering of vascular resistance, an increase in arterial flow and stimulates the use of oxygen and glucose. Nicergolina [Dcit] also improves blood circulation in the lungs and limbs and has been shown to inhibit blood platelet aggregation.

Additional information about Nicergolina [Dcit]

Nicergolina [Dcit] Indication: For the treatment of senile dementia, migraines of vascular origin, transient ischemia, platelet hyper-aggregability, and macular degeneration.
Mechanism Of Action: Nicergolina [Dcit] acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation. Therefore the mechanism of Nicergolina [Dcit] is to increase vascular circulation in the brain, thereby enhancing the transmission of nerve signals across the nerve fibres, which secrete acetylcholine as a neural transmitter.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Nicergoline
Synonyms: Not Available
Drug Category: Nootropic Agents; Vasodilator Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Nicergoline: MNE; Nargoline; Nicergolin [German]; Nicergolina [Dcit]; Nicergoline [Usan:Ban:Inn:Jan]; Nicergolinum [Inn-Latin]; Nicotergoline; Nimergoline; Nimergoline Base; Sermion; Vasospan;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Nicergolina [Dcit]: Not Available
Chemical IUPAC Name: Not Available
Chemical Formula: C24H26BrN3O3
Nicergoline on Wikipedia: http://en.wikipedia.org/wiki/Nicergoline
Organisms Affected: Humans and other mammals

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