Nicovel - General Information:

A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has pellagra-curative, vasodilating, and antilipemic properties. [PubChem]

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Nicovel - Pharmacology:

Nicovel and niacinamide are indicated for prevention and treatment of vitamin B3 deficiency states. Vitamin B3 (Nicovel) also acts to reduce LDL cholesterol, triglycerides, and HDL cholesterol. The magnitude of individual lipid and lipoprotein responses may be influenced by the severity and type of underlying lipid abnormality. The increase in total HDL is associated with a shift in the distribution of HDL subfractions (as defined by ultra-centrifugation) with an increase in the HDL2:HDL3 ratio and an increase in apolipoprotein A-I content. Vitamin B3 (Nicovel) treatment also decreases the serum levels of apolipoprotein B-100 (apo B), the major protein component of the VLDL (very low-density lipoprotein) and LDL fractions, and of lipoprotein-a, a variant form of LDL independently associated with coronary risk.

Nicovel for patients

Patient Information:

Diabetic patient and patient with liver problems or peptic ulcer should take
niacin with caution and should monitor liver funtion test, blood glucose
frequently.

Niacin should also used with caution in patients with elevated uric acid levels,
gout, unstable angina, and acute phase of myocardial infarction.

Niacin may interact with some antihypertensive drugs, aspirin, and alcohol. Patient should
check with a health professional before start taking niacin or start a new medication.

Nicovel Interactions

Interactions for Vitamin B3 (Niacin):

Antihypertensive Therapy: Nicotinic acid may potentiate the effects of ganglionic blocking agents and vasoactive drugs resulting in postural hypotension.

Aspirin: Concomitant aspirin may decrease the metabolic clearance of nicotinic acid. The clinical relevance of this finding is unclear.

Other: Concomitant alcohol or hot drinks may increase the side effects of flushing and pruritus and should be avoided at the time of drug ingestion.

Nicovel Contraindications

Contraindications for Vitamin B3 (Niacin):

Nicotinic acid is contraindicated in patients with a known hypersensitivity to any component of this medication; significant or unexplained hepatic dysfunction; active peptic ulcer disease; or arterial bleeding.

Nicovel more info

Indication, Mechanism Of Action, Drug Interactions, Food Interactions, etc..