Nifluril - General Information:

An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis. [PubChem]

Pharmacology:

Niflumic acid, a nonsteroidal anti-inflammatory fenamate, is a Ca2+-activated Cl- channel blocker.

Additional information about Nifluril

Nifluril Indication: Used in the treatment of rheumatoid arthritis.
Mechanism Of Action: Not Available
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Niflumic Acid
Synonyms: 2-[(3-Trifluoromethyl)Phenyl]Amino-3-Pyridine-Carboxylic Acid; Niflumate; Nifluminic acid; NFL; NFA; Lopac-N-0630; Acidum niflumicum [inn-latin]; Acido niflumico [inn-spanish]; Acide niflumique [inn-french]; 2-[3-(Trifluoromethyl)anilino]nicotinic acid; 2-(alpha,alpha,alpha-Trifluoro-m-toluidino)nicotinic acid; 2-(3-Trifluoromethyl-phenylamino)-nicotinic acid; 2-(3-(Trifluoromethyl)anilino)nicotinic acid; 2-(3-(Trifluoromethyl)-phenyl)aminonicotinic acid
Drug Category: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors
Drug Type: Small Molecule; Approved
Other Brand Names containing Niflumic Acid: Actol; Niflam; Nifluril; Landruma; Forenol; Flogovital;
Absorption: Well absorbed following oral administration.
Toxicity (Overdose): Oral, mouse: LD50 = 350 mg/kg; Oral, rat: LD50 = 250 mg/kg
Protein Binding: 90% bound to plasma proteins.
Biotransformation: Hepatic.
Half Life: 2.5 hours
Dosage Forms of Nifluril: Not Available
Chemical IUPAC Name: 2-[[3-(trifluoromethyl)phenyl]amino]pyridine-3-carboxylic acid
Chemical Formula: C13H9F3N2O2
Niflumic Acid on Wikipedia: Not Available
Organisms Affected: Humans and other mammals

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