Novo-Chlorpromazine - General Information:

The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine&

Pharmacology:

Novo-Chlorpromazine is a psychotropic agent indicated for the treatment of schizophrenia. It also exerts sedative and antiemetic activity. Novo-Chlorpromazine has actions at all levels of the central nervous system-primarily at subcortical levels-as well as on multiple organ systems. Novo-Chlorpromazine has strong antiadrenergic and weaker peripheral anticholinergic activity; ganglionic blocking action is relatively slight. It also possesses slight antihistaminic and antiserotonin activity.

Novo-Chlorpromazine for patients

PATIENT INFORMATION

Please follow the link below for more information and the links in Drug_reference region in DrugBank.

http://www.rxlist.com/cgi/generic3/chlorpromazine_wcp.htm

Novo-Chlorpromazine Interactions

The concurrent use of two or more drugs with anticholinergic activity--such as an antipsychotic drug (eg, chlorpromazine), an antiparkinsonian drug (eg, trihexyphenidyl), and/or a tricyclic antidepressant (eg, amitriptyline)--commonly results in excessive anticholinergic effects, including dry mouth and associated dental complications, blurred vision, and, in patients exposed to high temperature and humidity, hyperpyrexia.

Interactions may also occur with the following: anti-depressants/anti-anxiety drugs, drugs used to treat an overactive thyroid, beta-blockers (e.g., propranolol), sparfloxacin, grepafloxacin, guanethidine, guanadrel, metrizamide, cabergoline, lithium, narcotic pain medication (e.g., codeine), drugs used to aid sleep, drowsiness-causing antihistamines (e.g., diphenhydramine), any other drugs that may make you drowsy.

Novo-Chlorpromazine Contraindications

Do not use in patients with known hypersensitivity to phenothiazines. Do not use in comatose states or in the presence of large amounts of central nervous system depressants (alcohol, barbiturates, narcotics, etc.).

Additional information about Novo-Chlorpromazine

Novo-Chlorpromazine Indication: For the treatment of schizophrenia, control nausea and vomiting, For relief of restlessness and apprehension before surgery, adjunct in the treatment of tetanus, control the manifestations of the manic type of manic-depressive illness.
Mechanism Of Action: Novo-Chlorpromazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects).
Additionally, Novo-Chlorpromazine is a weak presynaptic inhibitor of Dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use).
Drug Interactions: Amphetamine Decreased anorexic effect, may increase psychotic symptoms
Benzphetamine Decreased anorexic effect, may increase psychotic symptoms
Bromocriptine The phenothiazine decreases the effect of bromocriptine
Cisapride Increased risk of cardiotoxicity and arrhythmias
Diethylpropion Decreased anorexic effect, may increase psychotic symptoms
Donepezil Possible antagonism of action
Fenfluramine Decreased anorexic effect, may increase psychotic symptoms
Galantamine Possible antagonism of action
Gatifloxacin Increased risk of cardiotoxicity and arrhythmias
Grepafloxacin Increased risk of cardiotoxicity and arrhythmias
Guanethidine The agent decreases the effect of guanethidine
Levofloxacin Increased risk of cardiotoxicity and arrhythmias
Mazindol Decreased anorexic effect, may increase psychotic symptoms
Meperidine Increased sedation and hypotension
Mesoridazine Increased risk of cardiotoxicity and arrhythmias
Phenmetrazine Decreased anorexic effect, may increase psychotic symptoms
Phentermine Decreased anorexic effect, may increase psychotic symptoms
Phenylpropanolamine Decreased anorexic effect, may increase psychotic symptoms
Pindolol Increased effect of both drugs
Propranolol Increased effect of both drugs
Rivastigmine Possible antagonism of action
Sparfloxacin Increased risk of cardiotoxicity and arrhythmias
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Thioridazine Increased risk of cardiotoxicity and arrhythmias
Ziprasidone Increased risk of cardiotoxicity and arrhythmias
Dextroamphetamine Decreased anorexic effect, may increases psychotic symptoms
Dexfenfluramine Decreased anorexic effect, may increases psychotic symptoms
Methamphetamine Decreased anorexic effect, may increases psychotic symptoms
Phendimetrazine Decreased anorexic effect, may increases psychotic symptoms
Metrizamide Increased risk of convulsions
Food Interactions: Take with food to reduce irritation.
Avoid alcohol.
Generic Name: Chlorpromazine
Synonyms: Not Available
Drug Category: Antipsychotics; Antiemetics; Dopamine Antagonists; Phenothiazines
Drug Type: Small Molecule; Approved
Other Brand Names containing Chlorpromazine: Chlorpromanyl-20; Chlorpromanyl-40; Chlorpromazine Hydrochloride Intensol; Largactil Liquid; Largactil Oral Drops; Novo-Chlorpromazine; Thorazine Spansule;
Absorption: Not Available
Toxicity (Overdose): Agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, restlessness
Protein Binding: 40%
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Novo-Chlorpromazine: Tablet Oral
Liquid Intravenous
Chemical IUPAC Name: 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
Chemical Formula: C17H19ClN2S
Chlorpromazine on Wikipedia: http://en.wikipedia.org/wiki/Chlorpromazine
Organisms Affected: Humans and other mammals

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