Omcilon - General Information:

A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)

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Pharmacology:

Omcilon and its derivatives are synthetic glucocorticoids that are used for their antiinflammatory or immunosuppressive properties.

Omcilon for patients

Patients being treated with Azmacort Inhalation Aerosol should receive the following information and instructions. This information is intended to aid them in the safe and effective use of this medication. It is not a complete disclosure of all possible adverse or intended effects.

Patients should use Azmacort Inhalation Aerosol at regular intervals as directed. Results of clinical trials indicate that significant improvement in asthma may occur by 1 week, but maximum benefit may not be achieved for 2 weeks or more. The patient should not increase the prescribed dosage but should contact the physician if symptoms do not improve or if the condition worsens.

In clinical studies and post-marketing experience with Azmacort Inhalation Aerosol, local infections of the oropharynx with Candida albicans have occurred. When such an infection develops, it should be treated with appropriate local or systemic (i.e., oral antifungal) therapy while remaining on treatment with Azmacort Inhalation Aerosol. However, at times therapy with Azmacort Inhalation Aerosol may need to be interrupted.

Patients should be instructed to track their use of Azmacort Inhalation Aerosol and to dispose of the canister after 240 actuations since reliable dose delivery cannot be assured after 240 doses.

Patients who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chickenpox or measles and if exposed, to obtain medical advice.

Omcilon Interactions

Omcilon Contraindications

Azmacort Inhalation Aerosol is contraindicated in the primary treatment of status asthmaticus or other acute episodes of asthma where intensive measures are required.

Hypersensitivity to triamcinolone acetonide or any of the other ingredients in this preparation contraindicates its use.

Additional information about Omcilon

Omcilon Indication: For the treatment of perennial and seasonal allergic rhinitis.
Mechanism Of Action: The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition of arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Triamcinolone
Synonyms: Triamcinolone acetonide; Triamcinolone diacetate; Triamcinolone hexacetonide; Fluoxiprednisolone; Fluoxyprednisolone; Tiamcinolonum [Inn-Latin]; Triamcinalone; Triamcinolona [Inn-Spanish]; Triamcinolonum [Inn]
Drug Category: Glucocorticoids; Anti-inflammatory Agents; Adrenergic Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Triamcinolone: Adcortyl; Aristocort; Aristocort A; Aristocort Tablets; Aristogel; Aristospan; Azmacort; Celeste; Cinolone; Cinolone-T; Delphicort; Flutex; Kenacort; Kenacort-A; Kenacort-Ag; Kenalog; Kenalog in Orabase; Kenalog-10; Kenalog-40; Kenalog-H; Ledercort; Nasacort; Nasacort Aq; Nasacort Hfa; Omcilon; Omicilon; Oracort; Oralone; Orion; Polcortolon; Rodinolone; Sk-Triamcinolone; Tri-Nasal; Triacet; Triacort; Triam-Tablinen; Triamcet; Triamcinlon; Triamcinolon; Triatex; Tricortale; Triderm; Trymex; Vetalog; Volon; Trilone; Volon A; Tristoject; Fougera;
Absorption: Rapid absorption following oral administration
Toxicity (Overdose): LD50=>500mg/kg (in rats)
Protein Binding: 68%
Biotransformation: Hepatic.
Half Life: 88 minutes
Dosage Forms of Omcilon: Paste Dental
Ointment Topical
Spray Nasal
Suspension Intrasynovial
Cream Topical
Suspension Intramuscular
Aerosol, metered Nasal
Suspension Intra-articular
Liquid Intramuscular
Chemical IUPAC Name: (8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Chemical Formula: C21H27FO6
Triamcinolone on Wikipedia: http://en.wikipedia.org/wiki/Triamcinolone
Organisms Affected: Humans and other mammals

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Thu, 01 Feb 2007
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