Orthoclone OKT3 (Ortho Biotech) - General Information:

Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Orthoclone OKT3 (Ortho Biotech) is 93% monomeric immune globulin G type 2a (IgG2a).

Pharmacology:

Used in organ transplant prophylaxis, Orthoclone OKT3 (Ortho Biotech) or OKT-3 binds specifically to the CD-3 complex, which is involved in antigen recognition and cell stimulation, on the surface of T lymphocytes. Immediately after administration CD-3-positive T lymphocytes are abruptly removed from circulation. It has been effective in reversing corticosteroid-resistant acute rejection in renal, liver, and cardiac transplant recipients.

Additional information about Orthoclone OKT3 (Ortho Biotech)

Orthoclone OKT3 (Ortho Biotech) Indication: For treatment of organ transplant recipients, prevention of organ rejection
Mechanism Of Action: Orthoclone OKT3 (Ortho Biotech) binds to the T-cell surface glycoprotein CD3 epsilon chain. It appears to kill CD-3 positive cells by inducing Fc mediated apoptosis, antibody mediated cytotoxicity and complement-dependent cytotoxicity.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Muromonab
Synonyms: AntiCD3; Muromonab-CD3
Drug Category: Immunomodulatory Agents; Immunosuppressive Agents
Drug Type: Biotech; Approved
Other Brand Names containing Muromonab: Orthoclone OKT3 (Ortho Biotech);
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Most likely removed by opsonization via the reticuloendothelial system when bound to T lymphocytes, or by human antimurine antibody production
Half Life: 0.8 hours (mammalian reticulocytes, in vitro)
Dosage Forms of Orthoclone OKT3 (Ortho Biotech): Solution Intravenous
Chemical IUPAC Name: Murine anti-CD3 antibody
Chemical Formula: C6460H9946N1720O2043S56
Muromonab on Wikipedia: http://en.wikipedia.org/wiki/Muromonab
Organisms Affected: Humans and other mammals

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