Ospen - General Information:

A broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms. [PubChem]

Pharmacology:

Ospen is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Ospen has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Ospen results from the inhibition of cell wall synthesis and is mediated through Ospen binding to penicillin binding proteins (PBPs). Ospen is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.

Ospen for patients

Penicillin V potassium is an antibiotic used to treat a variety of infections, most notably strep throat. This drug is also used to prevent infections (bacterial endocarditis) in patients with congenital heart disease or rheumatic or other acquired valvular heart disease. Penicillin is taken before dental procedures and surgical procedures in these patients. This drug should not be used by those with allergies to penicillin and you should consult with your pharmacist or physician if you are allergic to penicillin before taking this medication. The most common side effects from penicillin include: nausea, vomiting, epigastric distress, and diarrhea. Because this medication is used to treat infections, it should be taken as prescribed. Even if your symptoms are better, the entire supply of medication should be taken to ensure the infection is cured. Liquid forms of penicillin must be refrigerated and shaken before administered.

Ospen Interactions

No information provided.

Ospen Contraindications

A previous hypersensitivity reaction to any penicillin is a contraindication.

Additional information about Ospen

Ospen Indication: For the treatment of mild to moderately severe infections (e.g. dental infection, infections in the heart, middle ear infections, rheumatic fever, scarlet fever, skin infections, upper and lower respiratory tract infections) due to microorganisms
Mechanism Of Action: By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Ospen inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Ospen interferes with an autolysin inhibitor.
Drug Interactions: Methotrexate The penicillin increases the effect and toxicity of methotrexate
Demeclocycline Possible antagonism of action
Doxycycline Possible antagonism of action
Methacycline Possible antagonism of action
Minocycline Possible antagonism of action
Oxytetracycline Possible antagonism of action
Rolitetracycline Possible antagonism of action
Tetracycline Possible antagonism of action
Ethinyl Estradiol This anti-infectious agent could decrease the effect of the oral contraceptive
Mestranol This anti-infectious agent could decrease the effect of the oral contraceptive
Food Interactions: Not Available
Generic Name: Penicillin V
Synonyms: Fenossimetilpenicillina [Dcit]; Fenoximetilpenicilina [Inn-Spanish]; Penicillin Phenoxymethyl; Penicillin V Potassium; Phenoxymethylpenicillinic Acid; Phenoxymethylpenicillinic Acid Potassium Salt; Phenoxymethylpenicillin Potassium; Phenoxymethylenepenicillinic Acid; Phenoxymethyl Penicillin; Phenoximethylpenicillinum
Drug Category: Anti-Bacterial Agents; Penicillins
Drug Type: Small Molecule; Approved
Other Brand Names containing Penicillin V: Acipen V; Apopen; Beepen-Vk; Beromycin; Betapen-Vk; Calcipen; Compocillin V; Crystapen V; Distaquaine V; Eskacillian V; Eskacillin V; Fenacilin; Fenospen; Fenoxypen; Ledercillin Vk; Meropenin; Oracillin; Oratren; Ospen; Pen-Oral; Pen-V; Pen-Vee; Pen-Vee K; Penapar-Vk; Penicillin Vk; Penicillin-Vk; Pfizerpen Vk; Phenocillin; Phenomycilline; Phenopenicillin; Robicillin; Rocilin; Stabicillin; Uticillin Vk; V-Cil; V-Cillin; V-Cillin K; V-Cylina; V-Cyline; V-Tablopen; Vebecillin; Veetids; Veetids '125'; Veetids '250'; Veetids '500';
Absorption: 25% of the dose given is absorbed,50-60% bioavailable
Toxicity (Overdose): LD50 >1040 mg/kg (Orally in rats with Sodium salt); Nausea, vomiting, stomach pain, diarrhea, and, in rare cases, major motor seizures
Protein Binding: 80%
Biotransformation: Hepatic
Half Life: 30 to 40 minutes
Dosage Forms of Ospen: Powder, for solution Oral
Tablet Oral
Suspension Oral
Chemical IUPAC Name: (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[[2-(phenoxy)acetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Chemical Formula: C16H18N2O5S
Penicillin V on Wikipedia: http://en.wikipedia.org/wiki/Penicillin_V
Organisms Affected: Enteric bacteria and other eubacteria

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