Pantopan - General Information:

Pantopan is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.

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ProtonixGeneric Protonix (Pantoprazole) - 20mg 90 pills for $52.92
Protonix (Pantoprazole) is a Proton Pump Inhibitor (PPI) used to treat ulcers, Gastroesophageal Reflux Disease (GERD), erosive esophagitis, or Zollinger-Ellison syndrome. This medicine works by blocking acid production in the stomach. It may be used in combination with antibiotics including amoxicillin or clarithromycin to treat certain types of ulcers. It may also be used to treat other conditions as determined by your doctor.


Pantopan is a substituted benzimidazole indicated for the short-term treatment (up to 16 weeks) in the healing and symptomatic relief of erosive esophagitis. Pantopan is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production.

Pantopan for patients

Patients should be cautioned that PROTONIX Delayed-Release Tablets should not be split, crushed or chewed. The tablets should be swallowed whole, with or without food in the stomach. Concomitant administration of antacids does not affect the absorption of pantoprazole.

Pantopan Interactions

Pantoprazole is metabolized through the cytochrome P450 system, primarily the CYP2C19 and CYP3A4 isozymes, and subsequently undergoes Phase II conjugation.

Based on studies evaluating possible interactions of pantoprazole with other drugs, no dosage adjustment is needed with concomitant use of the following: theophylline, cisapride, antipyrine, caffeine, carbamazepine, diazepam (and its active metabolite, desmethyldiazepam), diclofenac, naproxen, piroxicam, digoxin, ethanol, glyburide, an oral contraceptive (levonorgestrel/ethinyl estradiol), metoprolol, nifedipine, phenytoin, warfarin, midazolam, clarithromycin, metronidazole, or amoxicillin. Clinically relevant interactions of pantoprazole with other drugs with the same metabolic pathways are not expected. Therefore, when coadministered with pantoprazole, adjustment of the dosage of pantoprazole or of such drugs may not be necessary. There was also no interaction with concomitantly administered antacids. There have been postmarketing reports of increased INR and prothrombin time in patients receiving proton pump inhibitors, including pantoprazole, and warfarin concomitantly. Increases in INR and prothrombin time may lead to abnormal bleeding and even death. Patients treated with proton pump inhibitors and warfarin concomitantly should be monitored for increases in INR and prothrombin time.

Because of profound and long lasting inhibition of gastric acid secretion, pantoprazole may interfere with absorption of drugs where gastric pH is an important determinant of their bioavailability (eg, ketoconazole, ampicillin esters, and iron salts).

Laboratory Tests

There have been reports of false-positive urine screening tests for tetrahydrocannabinol (THC) in patients receiving most proton pump inhibitors, including pantoprazole. An alternative confirmatory method should be considered to verify positive results.

Pantopan Contraindications

PROTONIX Delayed- Release Tablets are contraindicated in patients with known hypersensitivity to any component of the formulation.


Additional information about Pantopan

Pantopan Indication: Short-term (up to 16 weeks) treatment of erosive esophagitis.
Mechanism Of Action: Pantopan is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production by forming a covalent bond to two sites of the (H+,K+ )- ATPase enzyme system at the secretory surface of the gastric parietal cell. This effect is dose- related and leads to inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus.
Drug Interactions: Atazanavir This gastric pH modifier decreases the levels/effects of atazanavir
Dasatinib Possible decreased levels of dasatinib
Enoxacin The agent decreases the absorption of enoxacin
Indinavir Omeprazole decreases the absorption of indinavir
Itraconazole The proton pump inhibitor decreases the absorption of imidazole
Ketoconazole The proton pump inhibitor decreases the absorption of imidazole
Food Interactions: Not Available
Generic Name: Pantoprazole
Synonyms: Pantoprazol [Inn-Spanish]; Pantoprazole Na; Pantoprazole Sodium; Pantoprazolum [Inn-Latin]; Pantoprozole
Drug Category: Anti-Ulcer Agents; Proton-pump Inhibitors
Drug Type: Small Molecule; Approved
Other Brand Names containing Pantoprazole: Pantoloc; Protonix; Protonix I.V.; Protonix IV; Pantopan; Protium; Pantozol; Pantor; Astropan;
Absorption: Pantoprazole is well absorbed. It undergoes little first-pass metabolism resulting in an absolute bioavailability of approximately 77%.
Toxicity (Overdose): Single intravenous doses of pantoprazole at 378, 230, and 266 mg/kg (38, 46, and 177 times the recommended human dose based on body surface area) were lethal to mice, rats and dogs, respectively. The symptoms of toxicity included hypoactivity, ataxia, hunched sitting, limb-splay, lateral position, segregation, absence of ear reflex, and tremor. There is limited experience regarding cases of human overdosage, and treatment should be symptomatic and supportive.
Protein Binding: 98%
Biotransformation: Pantoprazole is extensively metabolized in the liver through the cytochrome P450 (CYP) system. The main metabolic pathway is demethylation, by CYP2C19, with subsequent sulfation; other metabolic pathways include oxidation by CYP3A4. There is no evidence that any of the pantoprazole metabolites have significant pharmacologic activity.
Half Life: 1 hour
Dosage Forms of Pantopan: Powder, for solution Intravenous
Tablet, coated Oral
Chemical IUPAC Name: 6-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzimidazole
Chemical Formula: C16H15F2N3O4S
Pantoprazole on Wikipedia:
Organisms Affected: Humans and other mammals

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